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Effect of irradiation on Concanavalin A-induced suppression of mitogen responses in human lymphocyte cultures

Effect of irradiation on Concanavalin A-induced suppression of mitogen responses in human lymphocyte cultures

International Archives of Allergy and Applied Immunology 67(1): 57-60

Concanavalin a (Con A)-induced and Con A-inducible human suppressor lymphocytes were examined for their radiosensitivity (16 Gy). It was observed that X-ray exposure of Con A-induced suppressor cells abolished some of the suppressive activity. Exposure of lymphocyte preparations did not prevent the subsequent induction by Con A of suppressor cells capable of inhibiting mitogen responses of lymphocytes. The relative size of the Con A-inducible suppressor population in the blood was not changed in breast cancer patients after local radiation therapy.

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Accession: 042915145

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PMID: 6460004

DOI: 10.1159/000232988

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