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Effect of miskleron (clofibrate) on dimethylhydrazine induction of intestinal tumors in rats



Effect of miskleron (clofibrate) on dimethylhydrazine induction of intestinal tumors in rats



Biulleten' Eksperimental'noi Biologii i Meditsiny 90(9): 350-352



Intestinal tumors were induced in male rats by dimethylhydrazine (14 mg/kg body weight subcutaneously once a week during 20 weeks). Part of animals received clofibrat per os in a dose of 25 mg a day 5 times a week. Clofibrat did not influence the frequency of the development of intestinal tumors but significantly decreased the number of medium-size and large tumors. The possible mechanisms of clofibrat action as well as the use of clofibrat and some related agents in oncology are discussed.

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Accession: 042918765

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PMID: 7426739



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