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Effect of neuroleptics on foot-pedal self stimulation from the ventral tegmentum mesencephali in rats and its correlation with cataleptogenic action



Effect of neuroleptics on foot-pedal self stimulation from the ventral tegmentum mesencephali in rats and its correlation with cataleptogenic action



Farmakologiia i Toksikologiia 45(2): 19-22



Experiments on rats have shown that droperidol, fluorophenazine, haloperidol, triphtazine, aminazin, thioridazin and clozapin are capable to reduce pedal self-stimulation from the ventral tegmen of the midbrain, which is not related to the cataleptogenic action of the neuroleptics or to their effect on the actuating motor mechanisms but is a consequence of the action on the emotional-positive reinforcement system. A significant positive correlation was disclosed between the ability of the neuroleptics given in effective doses to reduce pedal self-stimulation from the ventral tegmen and their cataleptogenic action.

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Accession: 042919825

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PMID: 6122595


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