Effect of potassium on the release of [3H]noradrenaline from rabbit and human pulmonary artery
Vizi, E.S.; Török, T.; Magyar, K.
Journal of Neurochemistry 42(3): 670-676
1984
ISSN/ISBN: 0022-3042 PMID: 6693896 DOI: 10.1111/j.1471-4159.1984.tb02735.x
Accession: 042924523
The release of [3H]noradrenaline ( [3H]NA) from rabbit and human isolated pulmonary artery has been measured. Removal of external potassium ions enhanced both the resting and stimulated release of [3H]NA from the strips. On adding K+ to tissues which had been suspended in K+-free Krebs solution, the release of [3H]NA was reduced in both stimulated and unstimulated tissues. Selective inhibition of presynaptic alpha 2-adrenoceptors by yohimbine significantly potentiated the release of [3H]NA evoked by stimulation in K+-free solution. The presynaptic inhibitory effect of NA was much less pronounced when the release was enhanced by the removal of external K+. Since the activity of NA, K-ATPase may be affected by removing K+ or by adding it to tissue previously kept in K+-free solution, the results may indicate involvement of the sodium pump in NA release.
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