Section 43
Chapter 42,926

Effect of prostaglandin E2, cAMP and histamine on glycoprotein synthesis in isolated cells of the rat gastric mucosa

Tairov, M.M.; Bersimbaev, R.I.; Salganik, R.I.

Biokhimiia 49(1): 25-31


ISSN/ISBN: 0320-9725
PMID: 6322869
Accession: 042925928

Download citation:  

It was discovered that prostaglandin E2 (PGE2), but not histamine, increased the incorporation of 3H-N-acetyl-D-glucosamine and 14C-amino acids into the acid-insoluble protein fraction of isolated, mainly mucoid cells of rat gastric mucosa. The cAMP at the dose of 1 mM enhanced, like the PGE2, the synthesis of gastric mucoids. Cycloheximide inhibited the basal incorporation of labelled N-acetyl-D-glucosamine and the amino acid mixture by 28 and 72%, respectively, and blocked completely the PGE2 effect on glycoproteins formation. It is suggested that the PGE2, unlike histamine, enhances the biosynthesis of glycoproteins in the mucoid cells of rat gastric mucosa. The cAMP is believed to be a messenger of the PGE2 effect.

Full Text Article emailed within 1 workday: $29.90