+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of tris (hydroxymethyl) aminomethane on amine oxidase activity in dog brain, liver and serum and in human placenta

Effect of tris (hydroxymethyl) aminomethane on amine oxidase activity in dog brain, liver and serum and in human placenta

Japanese Journal of Pharmacology 31(5): 737-746

The effect of Tris (hydroxymethyl) aminomethane on mitochondrial monoamine oxidase (MAO) activity in dog brain and liver and in human placenta was studied and the results obtained were compared with results on dog serum amine oxidase. With benzylamine as substrate, Tris did not inhibit mitochondrial MAO activity in these preparations, whereas inhibited mitochondrial MAO activity in these preparations, whereas it inhibited amine oxidase activity in a serum preparation. However, with tyramine, 5-hydroxytryptamine or beta-phenylethylamine as substrate, Tris inhibited MAO activity in all these preparations and its mode of inhibition was found to be non-competitive and reversible. The inhibition of Tris of MAO activity in these preparations was not due to decrease in the extent of extraction of aldehydes produced during the enzyme reaction. Moreover, increase in the oxygen tension did not change the extent of inhibition of MAO activity by Tris. From these results, it is concluded that with benzylamine as substrate, there is a remarkable difference in the effects of Tris on amine oxidase activity in mitochondrial and serum preparations. This difference in the inhibitions of mitochondria and serum is discussed.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 042936559

Download citation: RISBibTeXText

PMID: 7311169

DOI: 10.1254/jjp.31.737

Related references

Inhibition of rat liver threonine dehydratase by tris(hydroxymethyl) aminomethane (tris) and reversal by orthophosphate. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 139(1): 113-114, 1972

The effect of tris(hydroxymethyl) aminomethane on the potassium content and the membrane potential of liver cells. Journal of Pharmacology and Experimental Therapeutics 176(2): 434-440, 1971

The Effect of some Ions on the Activity of Beta-Galactosidase and the Inhibitory Effects of Tris (Hydroxymethyl) Aminomethane. Folia Microbiologica 24: 24-27, 1964

The effect of some ions on the activity of β-galactosidase and the inhibitory effect of tris (hydroxymethyl) aminomethane. Folia Microbiologica 9(1): 24-27, 1964

Effect of some organic acid salts of tris(hydroxymethyl)aminomethane in the incubation step on plasma renin activity. Clinica Chimica Acta; International Journal of Clinical Chemistry 105(1): 117-122, 1980

Effect of tris-hydroxymethyl-aminomethane on arterial blood, brain and cerebrospinal fluid acidosis after total cerebral ischemia in dogs. Kawasaki Igakkai Shi 19(1): 25-35, 1993

Age-related change in activation by Tris (hydroxymethyl) aminomethane on myosin-ATPase activity of human minor pectoral muscles. Mechanisms of Ageing and Development 31(2): 187-195, 1985

The correction of acidosis with tris(hydroxymethyl) aminomethane. Treatment of metabolic acidosis mixed respiratory and metabolic acidosis with tris(hydroxymethyl) aminomethane. Archives of Surgery 80: 693-697, 1960

3H]cocaine binding in brain is inhibited by Tris (hydroxymethyl) aminomethane. Journal of Neuroscience Methods 12(2): 151-154, 1984

Molecular characteristics of mono amine oxidase a in rat brain and liver and in human placenta. Neurochemical Research 6(7): 819-820, 1981

Acetylation of tris(hydroxymethyl)aminomethane (Tris) and Tris derivatives by carnitine acetyltransferase. Febs Letters 86(1): 99, 1978

A note on the synthesis of 5'-AMP ester of tris (hydroxymethyl)aminomethane by rat liver plasma membrane. Biochimica et Biophysica Acta 568(2): 485-487, 1979

Phosphorylation of tris(hydroxymethyl)aminomethane by human erythrocytes. Archives of Biochemistry and Biophysics 139(2): 311-319, 1970

Effect of tris(hydroxymethyl)aminomethane on ischemic myocardium. American Journal of Physiology 235(2): H167-H174, 1978

Renal effect of tris(hydroxymethyl)-aminomethane during CO2 load. American Journal of Physiology 204: 113-118, 1963