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Effects of adrenalectomy on energy balance, diet-induced thermogenesis and brown adipose tissue in adult cafeteria-fed rats

Rothwell, N.J.; Stock, M.J.; York, D.A.

Comparative Biochemistry and Physiology. A Comparative Physiology 78(3): 565-569

1984


ISSN/ISBN: 0300-9629
PMID: 6147234
DOI: 10.1016/0300-9629(84)90597-8
Accession: 042945386

Feeding adult male rats a palatable cafeteria diet stimulated energy intake and expenditure but also raised body weight and energy gains. Bilateral adrenalectomy (ADX) had little effect on stock-fed animals, but prevented the development of obesity in cafeteria-fed rats by depressing food intake and energetic efficiency. Adrenalectomy also markedly increased the thermogenic activity of brown adipose tissue, and depressed insulin levels, particularly in the cafeteria group.

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