+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of calmodulin inhibitor on histamine release from rat peritoneal mast cells induced by concanavalin A and ionophore A23187



Effects of calmodulin inhibitor on histamine release from rat peritoneal mast cells induced by concanavalin A and ionophore A23187



General Pharmacology 14(2): 273-275



The involvement of calmodulin in stimulus-secretion coupling of histamine release from rat mast cells was examined using a specific calmodulin inhibitor, W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide]. W-7 at low concentrations inhibited histamine release induced by either concanavalin A or ionophore A23187 and at high concentrations enhanced the release. But its congener, W-5 [N-(6-aminohexyl)-1-naphthalenesulfonamide], which has virtually no calmodulin-inhibiting activity, did not affect the release. It is concluded that W-7 modulates histamine release by inhibiting some functions of calmodulin in the cells.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 042948504

Download citation: RISBibTeXText

PMID: 6188646

DOI: 10.1016/0306-3623(83)90009-5


Related references

Effects of calmodulin inhibitor on histamine release from peritoneal mast cells induced by concanavalin a and ionophore a 23187 calcimycin. General Pharmacology 14(2): 273-276, 1982

Effect of 2450 MHz microwave radiation on concanavalin A or ionophore-induced histamine release from rat peritoneal mast cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 39(6): 671-675, 1981

Effect of 2450 megahertz microwave radiation on concanavalin a or ionophore induced histamine release from rat peritoneal mast cells. International Journal of Radiation Biology & Related Studies in Physics Chemistry & Medicine 39(6): 671-676, 1981

Mechanism of histamine release from rat mast cells induced by the ionophore A23187: effects of calcium and temperature. British Journal of Pharmacology 63(4): 643-649, 1978

Inhibition of calcium ionophore (A23187)-stimulated histamine release from rat peritoneal mast cells by azelastine: implications for its mode of action. European Journal of Pharmacology 96(3-4): 227-233, 1983

Inhibitory effects of Sasa senanensis Rehder extract (SE) on calcium-ionophore A23187-induced histamine release from rat peritoneal exudate cells. Japanese Journal of Pharmacology 79(4): 489-492, 1999

Inhibitory Effects of Sasa senanensis Rehder Extract (Se) on Calcium-Ionophore A23187-Induced Histamine Release From Rat Peritoneal Eudate Cells. The Japanese Journal of Pharmacology 79(4): 489-492, 1999

Inhibition of histamine release from rat peritoneal mast cells treated with the ionophore A23187. Implications for the mode of action of anti-allergic compounds. Agents and Actions 11(1-2): 44-50, 1981

Histamine release induced from rat mast cells by the ionophore A23187 in the absence of extracellular calcium. European Journal of Pharmacology 62(4): 329-334, 1980

Broncho-Vaxominhibits histamine release from rat mast cells induced by compound 48/80 and ionophore A23187. Inflammation Research 27(1-2): 43-45, 1989

Histamine release from rat mast cells induced by the ionophore A23187 in the absence of extracellular calcium. Inflammation Research 8(4): 394-394, 1978

Utilization of adenosine triphosphate in rat mast cells during histamine release induced by the ionophore A23187. British Journal of Pharmacology 65(1): 103-109, 1979

Histamine release from rat mast cells induced by the ionophore A23187 in the absence of extracellular calcium. Agents and Actions 8(4): 394, 1978

Further observations on the utilization of adenosine triphosphate in rat mast cells during histamine release induced by the ionophore A23187. British Journal of Pharmacology 69(4): 657-662, 1980

Broncho-Vaxom inhibits histamine release from rat mast cells induced by compound 48/80 and ionophore A23187. Agents and Actions 27(1-2): 43-45, 1989