Effects of external osmolality, calcium and prolactin on growth and differentiation of the epidermal cells of the cichlid teleost Sarotherodon mossambicus

Wendelaar Bonga, S.E.; Meis, S.

Cell and Tissue Research 221(1): 109-123

1981


ISSN/ISBN: 0302-766X
PMID: 7317938
DOI: 10.1007/bf00216574
Accession: 042953848

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Abstract
Osmolality and concentrations of divalent cations--calcium, and to a lesser extent magnesium--of the water are the main environmental factors that determine development and degree of mucification of the skin epithelium of Sarotherodon mossambicus. Epithelial thickness and number of mucocytes in fish exposed to low (freshwater level) concentrations of calcium and magnesium are directly related to the height of the osmotic gradient between water and blood plasma. No such relationship is found in fish exposed to a high (seawater level) concentration of calcium in the water, irrespective of the height of the osmotic gradient. The results strongly indicate that the effects of osmolality and divalent cations are indirect, and mediated by prolactin, since administration of ovine or fish prolactin stimulates growth and multiplication of the cells of the basal layer of the epidermis, and promotes the differentiation of the mucocytes.

Effects of external osmolality, calcium and prolactin on growth and differentiation of the epidermal cells of the cichlid teleost Sarotherodon mossambicus