Section 43
Chapter 42,958

Effects of interleukin-4 on granulocyte-macrophage-colony formation from murine bone marrow cells and hematopoietic reconstitution following murine allogeneic bone marrow transplantation

Zhu, K.; Atkinson, K.

Chinese Medical Sciences Journal 9(2): 125-128


ISSN/ISBN: 1001-9294
PMID: 7528067
Accession: 042957162

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We investigated the effects of mouse recombinant IL-4 on hematopoiesis in vitro and in vivo. IL-4 alone was found to be incapable of stimulating colony formation, but it inhibited both IL-3 and GM-CSF-induced colony formation by murine hematopoietic progenitor cells. In contrast, colony formation induced by G-CSF was enhanced in the presence of IL-4. We also studied the influence of IL-4 on hematopoietic reconstitution after allogeneic bone marrow transplantation in a murine model, and found that IL-4 had significant inhibitory effects on neutrophil recovery and that neutrophil recovery accelerated by IL-3 and G-CSF was significantly suppressed by IL-4. The combination of IL-4 and GM-CSF caused a significant decrease in the absolute number of neutrophils.

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