EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effects of local anesthetics on phorbol ester-induced ornithine decarboxylase activity in mouse and human skin


Anticancer Research 4(6): 363-366
Effects of local anesthetics on phorbol ester-induced ornithine decarboxylase activity in mouse and human skin
In preparation for experiments to determine the effects of various orally administered compounds on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ODC. Topically applied ethyl chloride had variable and unpredictable effects on ODC induction. Adequate local anesthesia can be obtained by using intradermal 1.0% procaine hydrochloride or normal saline; neither of these agents inhibited TPA induction of epidermal ODC activity in incubated human skin punch biopsies.

(PDF 0-2 workdays service: $29.90)

Accession: 042958516

PMID: 6517531



Related references

Effects of 1 25 dihydroxyvitamin d 3 and fluorinated analog on the ornithine decarboxylase activity and its gene expression in mouse skin induced by phorbol ester tumor promoter. Clinical Research 37(2): 629A, 1989

Sphingosine inhibits phorbol ester-induced inflammation, ornithine decarboxylase activity, and activation of protein kinase C in mouse skin. Journal of Investigative Dermatology 91(5): 486-491, 1988

Inhibitory effects of -gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Letters 129(2): 139-144, July 17, 1998

Prostratin, a nonpromoting phorbol ester, inhibits induction by phorbol 12-myristate 13-acetate of ornithine decarboxylase, edema, and hyperplasia in CD-1 mouse skin. Cancer Research 51(19): 5355-5360, 1991

Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor kappa B activation in mouse skin. International Journal of Cancer 100(4): 456-462, 2002

Inhibition of phorbol ester -induced mouse epidermal ornithine decarboxylase activity by Vaccinium macrocarpon AIT extracts. FASEB Journal 12(5): A831, March 20, 1998

Tannic acid inhibition of phorbol ester induced ornithine decarboxylase activity in mouse epidermis in vivo. Proceedings of the American Association for Cancer Research Annual Meeting 32: 151, 1991

Inhibition of phorbol ester -induced mouse epidermal ornithine decarboxylase activity by grape seed oligomeric proanthocyanidins. FASEB Journal 12(5): A831, March 20, 1998

Microwave irradiation a new rapid technique for separating epidermal tissue skin from mouse preserving rna dna protein and phorbol ester induced ornithine decarboxylase levels. Journal of Investigative Dermatology 69(6): 547-550, 1977

Microwave irradiation: a new rapid technique for separating epidermal tissue from mouse skin preserving RNA, DNA, protein and phorbol ester-induced ornithine decarboxylase levels. Journal of Investigative Dermatology 69(6): 547-550, 1977