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Effects of local anesthetics on phorbol ester-induced ornithine decarboxylase activity in mouse and human skin


, : Effects of local anesthetics on phorbol ester-induced ornithine decarboxylase activity in mouse and human skin. Anticancer Research 4(6): 363-366

In preparation for experiments to determine the effects of various orally administered compounds on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ODC. Topically applied ethyl chloride had variable and unpredictable effects on ODC induction. Adequate local anesthesia can be obtained by using intradermal 1.0% procaine hydrochloride or normal saline; neither of these agents inhibited TPA induction of epidermal ODC activity in incubated human skin punch biopsies.


Accession: 042958516

PMID: 6517531

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