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Effects of local anesthetics on phorbol ester-induced ornithine decarboxylase activity in mouse and human skin



Effects of local anesthetics on phorbol ester-induced ornithine decarboxylase activity in mouse and human skin



Anticancer Research 4(6): 363-366



In preparation for experiments to determine the effects of various orally administered compounds on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ODC. Topically applied ethyl chloride had variable and unpredictable effects on ODC induction. Adequate local anesthesia can be obtained by using intradermal 1.0% procaine hydrochloride or normal saline; neither of these agents inhibited TPA induction of epidermal ODC activity in incubated human skin punch biopsies.

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Accession: 042958516

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PMID: 6517531



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