+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of peripheral electric stimulation on the central 5-hydroxytryptamine in mice: relation to the peripheral stimulation-produced analgesia



Effects of peripheral electric stimulation on the central 5-hydroxytryptamine in mice: relation to the peripheral stimulation-produced analgesia



Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 77(4): 347-360



Effects of peripheral electric stimulation (PES) on the functional state of central 5-hydroxytryptamine (5-HT) and on the analgesic effect were investigated in mice. The PES was administered by a passing rectangular wave (0.45 mA, 5 msec, 5-100 Hz) for 2 hr through bipolar electrodes implanted subcutaneously at the base of the tail. Whole brain 5-HT concentration remained unchanged with the PES at 20 Hz, whereas 5-hydroxy-indoleacetic acid concentrations were significantly increased in the whole brain. A significant increase in the whole brain compared with that in control was already attained at 30 min after initiation of the PES. Number of head-twitches induced by 5-methoxy-N,N-dimethyltryptamine after the PES was clearly potentiated. Increase in the number of head-twitches after the PES was abolished by administration of p-chlorophenylalanine, a 5-HT depletor, and 5,6-dihydroxytryptamine, a 5-HT neurotoxin. The PES for 1 hr produced an antinociceptive effect. Administration of L-5-hydroxytryptophan enhanced the antinociceptive effect induced by PES, while methysergide and naloxone completely abolished this antinociception. Thus, 5-HT neurons are probably excited functionally by the PES, and the mechanisms of analgesia produced by the PES involve both endogenous opiate systems and central serotonergic mechanisms.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 042962147

Download citation: RISBibTeXText

PMID: 6974679


Related references

Effects of peripheral electric stimulation on central 5 hydroxy tryptamine in mice relation to the peripheral stimulation produced analgesia. Folia Pharmacologica Japonica 77(4): 347-360, 1981

Effects of peripheral electric stimulation on the central 5-hydroxytryptamine turnover and drug-induced head-twitches in mice. Brain Research 193(2): 594-597, 1980

Effects of methysergide and naloxone on analgesia induced by the peripheral electric stimulation in mice. Brain Research 208(2): 463-467, 1981

The relation of endorphins to analgesia produced by peripheral conditioning stimulation. Neuroscience Letters Suppl.(1): S435, 1978

Effects of peripheral electric stimulation on the central mono aminergic systems influences on 5 hydroxy tryptamine turnover and drug induced head twitches in mice. Japanese Journal of Pharmacology 29(Suppl.): 37P, 1979

A comparative study of the effects of magnetic stimulation and electric stimulation on peripheral nerve injury in rat. Journal of Tongji Medical University 21(2): 159-162, 2001

Endorphins and analgesia produced by peripheral conditioning stimulation. Bonica, J J , J C Liebeskind And D G Albe-Fessard (Ed ) Advances in Pain Research And Therapy, Vol 3 Proceedings Of The 2nd World Congress on Pain, Montreal, Que , Canada, Aug 27-Sept 1, 1978 Xxvii+956p Raven Press: New York, N Y , Usa Illus P587-592, 1979

Temporal characteristics of peripheral stimulation produced analgesia in the rat. Neuroscience Letters Suppl.(3): S265, 1979

The influence of naloxone on analgesia produced by peripheral conditioning stimulation. Brain Research 173(2): 295-302, 1979

The silent period produced by electric stimulation of mixed peripheral nerves. Muscle & Nerve 13(9): 874, 1990

Central and peripheral mechanisms in the stimulation of adrenocortical secretion by the 5-hydroxytryptamine-2 agonist, -1- -2-aminopropane. Journal of Pharmacology & Experimental Therapeutics 270(3): 918-928, 1994

Sandwich technique, peripheral nerve stimulation, peripheral field stimulation and hybrid stimulation for inguinal region and genital pain. British Journal of Neurosurgery 30(6): 631-636, 2016

Analgesia with peripheral nerve stimulation absence of a peripheral mechanism. Pain 15(1): 55-70, 1983

Peripheral stimulation in mice induces short-duration analgesia preventable by naloxone. European Journal of Pharmacology 58(2): 169-178, 1979

Cocaine: cardiovascular effects in relation to inhibition of peripheral neuronal monoamine uptake and central stimulation of the sympathoadrenal system. Journal of Pharmacology and Experimental Therapeutics 267(1): 153-162, 1993