Effects of propranolol on post-ischemic acute renal failure

Chevalier, R.L.; Finn, W.F.

Nephron 25(2): 77-81

1980


ISSN/ISBN: 1660-8151
PMID: 7354883
DOI: 10.1159/000181757
Accession: 042963660

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Abstract
The effects of constant intravenous infusion of propranolol, 1 mg/kg/h, on acute renal failure produced by 1 h occlusion of the left renal artery in the rat were investigated by clearance and micropuncture techniques. Propranolol infusion resulted in a significantly smaller rise in proximal intratubular pressure than that observed following renal ischemia in the saline-infused group. When compared with saline-infused animals, this effectwas accompanied by a significant improvement in inulin clearance without commensurate increase in renal blood flow or stop flow pressure and suggests attenuation of intratubular obstruction by the drug. A complex metabolic effect may be involved.