Effects of secretin and cholecystokinin-pancreozymin on pancreatic juice and insulin secretion of goats

Baile, C.A.; Glick, Z.; Mayer, J.

Journal of Dairy Science 52(4): 513-517


ISSN/ISBN: 0022-0302
PMID: 5813505
DOI: 10.3168/jds.s0022-0302(69)86596-3
Accession: 042965025

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Goats injected i/v with as much as 3.75 clinical Units of secretin per kg body wt. did not show an increased serum immunoreactive insulin level. An i/v injection of 5.6 Crick Units of cholecystokininpancreozymin (CP) per kg caused an immediate doubling of the serum immunoreactive insulin level, which returned to near normal after 3 to 5 min. The maximum dose tested of secretin was several times higher than that required to elicit the response in other species; CP caused less of a response in goats than in monogastric animals. The highly purified secretin and CP hormone preparations also affected the exocrine function of the pancreas at doses less than those tested above. Therefore, although secretin and CP cause exocrine secretion of the pancreas similar to that in monogastric animals, only CP causes insulin secretion in goats.