Effects of surfactants on the Gi absorption of beta-lactam antibiotics in rats

Miyamoto, E.; Tsuji, A.; Yamana, T.

Journal of Pharmaceutical Sciences 72(6): 651-654

1983


ISSN/ISBN: 0022-3549
PMID: 6410042
DOI: 10.1002/jps.2600720615
Accession: 042966911

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Abstract
The effects of various nonionic and ionic surfactants and two bile salts (sodium cholate and sodium taurocholate) on the GI absorption of beta-lactam antibiotics were investigated using the in situ rat GI perfusion technique. Addition of 10 mM polyoxyethylene-23-lauryl ether in the perfusion solution reduced the absorption of propicillin by the stomach and markedly increased the absorption of propicillin and cefazolin by the small intestine. Ester-type nonionic surfactants and bile salts exerted no significant influence on the intestinal absorption of these antibiotics.

Effects of surfactants on the Gi absorption of beta-lactam antibiotics in rats