Epithelial bladder tumor induction in rats with N- (4- (5-nitro-2-furyl) -2-thiazolyl) formamide

Vlasov, N.N.; Pliss, G.B.; Balin, V.V.

Voprosy Onkologii 26(3): 63-67


ISSN/ISBN: 0507-3758
PMID: 7368659
Accession: 043024131

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Among 20 white non-inbred rats of the "Rappolovo" nursery for laboratory animals of the USSR Academy of Medical Sciences, which were fed through all their life N-/4-(5-nitro-2-furyl)-2-thiazolyl/formamide in the concentration 0.188%, transition-cell vesical tumors developed in 4 animals at the 56th, 60th, 61st 70th week of the experiment. After 71--81 weeks since the onset of the experiment, cancer of this organ developed in the remaining 14 animals. The maximum total dose of the carcinogen was 14.4 g/ per rat. The maximum observation terms--567 days.