Experimental infection of cynomolgus monkeys with a human retrovirus, adult T-cell leukemia virus

Yamamoto, N.; Hayami, M.; Komuro, A.; Schneider, J.; Hunsmann, G.; Okada, M.; Hinuma, Y.

Medical Microbiology and Immunology 173(1): 57-64

1984


ISSN/ISBN: 0300-8584
PMID: 6088962
DOI: 10.1007/bf02123570
Accession: 043081778

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Abstract
The experimental infection of six cynomolgus monkeys with adult T-cell leukemia virus (ATLV) was attempted. Three animals were inoculated with living MT-2 cells and three with cell-free ATLV. All animals developed an antibody response to virus-specific glycopolypeptides and viral core polypeptides. ATLV-specific antigens appeared in peripheral lymphocytes from all six animals. Virus expression persisted in all animals. Up to 40 weeks after inoculation no animal developed any symptom of leukemia.

Experimental infection of cynomolgus monkeys with a human retrovirus, adult T-cell leukemia virus