Section 44
Chapter 43,109

Fall in the levels of circulating lymphoblasts caused by intravenous administration of the A50 monoclonal antibody in a patient with acute T-cell lymphoblastic leukemia. a step in the demonstration of serotherapy with monoclonal antibodies

Bernard, A.; Gosse, C.; Pico, J.; Faure, E.; Raynal, B.; Hayat, M.; Lemerle, J.; Charbord, P.; Boumsell, L.

La Nouvelle Presse Medicale 11(43): 3173-3178


ISSN/ISBN: 0301-1518
PMID: 6960319
Accession: 043108761

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In an 8-year-old boy with acute lymphoblastic leukaemia not previously treated intravenous administration of a single 8 mg dose of a monoclonal antibody that recognizes an epitope restricted to the surface of mature T-cells resulted, within 20 hours, in a fall in circulating lymphoblasts from 200 000 to 70 000. No adverse clinical or biological reaction was detected and no antigenic modulation occurred at lymphoblast surface. This observation constitutes a first step in the complex development of effective serotherapy for malignant diseases, using monoclonal antibodies.

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