+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Formation by diethylnitrosamine and persistence of O4-ethylthymidine in rat liver DNA in vivo

Formation by diethylnitrosamine and persistence of O4-ethylthymidine in rat liver DNA in vivo

Cancer Letters 10(1): 1-6

The formation by diethylnitrosamine (DEN) and persistence of O4-ethylthymidine in rat liver DNA in vivo has been studied using enzymic hydrolysis of DNA, cation exchange column chromatography and thin-layer chromatography (TLC). The amount of O4-ethylthymidine represented about 1% of the total ethylation; its half-life in vivo was 19 (range 16--24) days, the same value as obtained for O2-ethylthymidine. The persistence of O2- and O4-ethylthymidine, rather than the rapid removal of O6-ethylguanine, favours the former miscoding base adducts as relevant molecular lesions in rat liver carcinogenesis.

(PDF same-day service: $19.90)

Accession: 043146493

Download citation: RISBibTeXText

PMID: 7226125

DOI: 10.1016/0304-3835(80)90058-0

Related references

Formation of relatively persistent O2-ethylthymidine by diethylnitrosamine in rat liver DNA. Febs Letters 100(1): 191-194, 1979

Molecular dosimetry of o 2 ethylthymidine in liver dna of rats continuously exposed to diethylnitrosamine. Proceedings of the American Association for Cancer Research Annual Meeting 33: 148, 1992

Formation and persistence of ethylguanines in liver DNA of rainbow trout (Salmo gairdneri) treated with diethylnitrosamine by water exposure. Food and Chemical Toxicology 26(8): 699-704, 1988

Persistence and accumulation of micronuclei in hepatocytes of rats after repeated in-vivo administration of diethylnitrosamine. 2013

Kinetics of formation and persistence of ethylguanines in DNA of rats and hamsters treated with diethylnitrosamine. Cancer Research 45(5): 2076-2084, 1985

Persistence and accumulation of micronucleated hepatocytes in liver of rats after repeated administration of diethylnitrosamine. Mutation Research 755(2): 100-107, 2013

Persistence and accumulation of (potential) single strand breaks in liver DNA of rats treated with diethylnitrosamine or dimethylnitrosamine: correlation with hepatocarcinogenicity. Chemico-Biological Interactions 25(2-3): 229-242, 1979

Kinetics of induction and growth of precancerous liver-cell foci, and liver tumour formation by diethylnitrosamine in the rat. European Journal of Cancer 11(10): 689-696, 1975

In vivo methylation of rat liver RNA and under the influence of diethylnitrosamine. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 349(12): 1725-1732, 1968

In vivo repair of rat liver DNA damaged by dimethylnitrosamine or diethylnitrosamine. Chemico-Biological Interactions 19(1): 111-124, 1977

Formation of liver cancer by diethylnitrosamine in budgerigars. Naturwbsenschaften 53(17): 437, 1966

In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue. Free Radical Biology & Medicine 40(11): 2040-2046, 2006

Enhancing effect of co-administration of polychlorinated biphenyls and diethylnitrosamine on enzyme-altered islands induced by diethylnitrosamine in rat liver. Carcinogenesis 7(10): 1697-1700, 1986

Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors. Carcinogenesis 36(3): 378-389, 2015

Formation and subsequent excision of O6-ethylguanine from DNA of rat liver following administration of diethylnitrosamine. Cancer Research 39(12): 5003-5009, 1979