+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Gitelman syndrome in children: true hypokalemia but false Bartter syndrome

Gitelman syndrome in children: true hypokalemia but false Bartter syndrome

Archives de Pediatrie 1(10): 916-918

Gitelman's syndrome or familial hypokalemia-hypomagnesemia and Bartter syndrome share some common features but their prognosis is quite different. Four unrelated children, aged 5 to 12 years, were studied because they suffered from muscle cramps and/or abdominal pain. Supportive findings included: hypokalemia (2.1 to 2.9 mmol/l), metabolic alkalosis (31 to 34 mmol/l), hyperkaliuresis (5.8 to 7.1 mmol/kg/day), hypomagnesemia (0.58 to 0.64 mmol/l), hypermagnesuria (0.19 to 0.23 mmol/kg/day), hypocalciuria (0.012 to 0.021 mmol/kg/day). Blood pressure contrasting with high renin activity (19.04 to 20.03 ng/ml/hr) was normal. Chloride fractional excretion after oral water supplementation was only slighty decreased and hypercalciuric response to furosemide administration was not observed. Supplementation with magnesium chloride failed to correct hypomagnesemia while potassium chloride improved hypokalemia. Age of onset, tetany manifestations, absence of growth retardation, hypermagnesuria despite, hypomagnesemia, hypocalciuria not improved by furosemide favor the diagnosis of Gitelman's syndrome rather than that of Bartter syndrome initially considered.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 043197503

Download citation: RISBibTeXText

PMID: 7842074

Related references

Genetic screening for Bartter syndrome and Gitelman syndrome pathogenic genes among individuals with hypertension and hypokalemia. Clinical and Experimental Hypertension 2018: 1-8, 2018

Renal tubular function in children and adolescents with Gitelman's syndrome, the hypocalciuric variant of Bartter's syndrome. Nephrology, Dialysis, Transplantation 10(8): 1313-1319, 1995

Gitelman syndrome: a rare cause of hypokalemia-hypomagnesemia in children. Archives de Pediatrie 3(3): 293-294, 1996

5 children with hypokalemia, hypomagnesemia and hypocalciuria (Gitelman syndrome) in one family. Nederlands Tijdschrift Voor Geneeskunde 141(35): 1698-1701, 1997

Pseudo-Bartter's syndrome from surreptitious diuretic intake: differential diagnosis with true Bartter's syndrome. Nephrology, Dialysis, Transplantation 7(9): 896-901, 1992

Atrial natriuretic peptide in pseudo bartter's syndrome due to furosemide abuse and true bartter's syndrome. Medical Bulletin of Fukuoka University 13(3): 233-234, 1986

Bartter's syndrome and Gitelman's syndrome: two entities sharing the same abnormality of vascular reactivity. Clinical Nephrology 50(1): 65-67, 1998

Normal prostaglandinuria E2 in Gitelman's syndrome, the hypocalciuric variant of Bartter's syndrome. American Journal of Kidney Diseases 25(6): 824-828, 1995

Possible discrimination of Gitelman's syndrome from Bartter's syndrome by renal clearance study: report of two cases. American Journal of Kidney Diseases 25(4): 637-641, 1995

Atypical presentation and diagnosis of a case of Gitelman syndrome in the adult. How to distinguish between Bartter syndrome?. Anales de Medicina Interna 15(4): 208-210, 1998

Differential diagnosis of Gitelman's syndrome and Bartter's syndrome, apropos of a case of metabolic alkalosis. Revista Clinica Espanola 196(10): 725, 1996

Chronic hypokalaemia of adults: Gitelman's syndrome is frequent but classical Bartter's syndrome is rare. Nephrology, Dialysis, Transplantation 10(9): 1607-1613, 1995

Inappropriate secretion of antidiuretic hormone: true and false Schwartz-Bartter syndrome. Apropos of 2 cases. La Semaine des Hopitaux 53(11-12): 673-678, 1977

Bartter's syndrome and Gitelman's syndrome: Pathogenesis, pathophysiology, and therapy. Nihon Rinsho. Japanese Journal of Clinical Medicine 64 Suppl 2: 504-507, 2006

Gitelman's syndrome is genetically distinct from other forms of Bartter's syndrome. Pediatric Nephrology 10(5): 551-554, 1996