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Glucose uptake and insulin secretory responses to intravenous glucose loads in the dog



Glucose uptake and insulin secretory responses to intravenous glucose loads in the dog



American Journal of Veterinary Research 42(1): 155-158



Twenty-one healthy young non-anesthetized Dalmatian dogs (10 male, 11 female) were given IV glucose loads between 300 and 1,500 mg/kg of body weight in a standard time period of 30 s. The fractional glucose turnover rates and the insulin peak responses gradually increased with glucose loads to 1,000 mg/kg and the total insulin secretion with loads to 1,250 mg/kg and remained constant. The insulinogenic index (delta I/delta G) varied inversely with the size of the glucose loads. The pattern of responses indicates that the optimum glucose load is near 600 mg/kg for evaluating normal glucose metabolism in dogs by the IV glucose loading technique.

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Accession: 043201412

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PMID: 7013581


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