Glycine metabolism in rat liver mitochondria. V. Intramitochondrial localization of the reversible glycine cleavage system and serine hydroxymethyltransferase

Motokawa, Y.; Kikuchi, G.

Archives of Biochemistry and Biophysics 146(2): 461-464

1971


ISSN/ISBN: 0003-9861
PMID: 4107181
DOI: 10.1016/0003-9861(71)90149-4
Accession: 043203374

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Abstract
Intramitochondrial localization of the reversible glycine cleavage system and serine hydroxymethyltransferase was studied with the digitonin fractionation technique, and it was demonstrated that they are associated with the inner membrane of rat liver mitochondria. The effect of increasing the concentration of digitonin on the distribution pattern of mitochondrial enzymes has indicated that serine hydroxymethyltransferase is solubilized from the inner membrane fraction while the reversible glycine cleavage system is bound to the inner membrane.