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Hyperplasia in the spinal sensory system of the frog. I. Plasticity in the most caudal dorsal root ganglion



Hyperplasia in the spinal sensory system of the frog. I. Plasticity in the most caudal dorsal root ganglion



Journal of Comparative Neurology 221(4): 444-452



Increases in the amount of periphery available for innervation were achieved by the unilateral removal of hindlimb dorsal root ganglion (DRG) in Rana pipiens, a procedure which generally results in a compensatory cell number increased (hyperplasia) in the DRG which remain. The hyperplastic response is extremely variable and various factors which might control its production were investigated. The findings indicate that the pattern of DRG removed, the animal's age at the time of removal, and the survival period are not strictly related to the production of hyperplasia in hindlimb DRG. Special emphasis has been placed on DRG 10, the caudalmost DRG which normally innervates the cloaca and sends a small projection to the hindlimb. This DRG displayed dramatic cell number increases of up to 564%. Several unique features of the hyperplastic response have been observed in DRG 10. This DRG showed increases in cell number on both the operated and the unoperated sides. It showed hyperplasias in animals subjected to ganglionectomy past metamorphosis as well as during larval development. The production of DRG 10 hyperplasias exclusively occurred in male pre- and postmetamorphic animals. To account for these distinctive features of DRG 10 hyperplasia, baseline studies of the normal course of proliferation and cell death in DRG 10 were undertaken. They reveal no fundamental developmental differences between DRG 10 and other hindlimb DRG. Other mechanisms responsible for these unusual features of developmental plasticity in DRG 10 are discussed.

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Accession: 043302286

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PMID: 6607269

DOI: 10.1002/cne.902210407


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