+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immunoglobulins and non-organ-specific antibodies in alcoholic liver cirrhosis



Immunoglobulins and non-organ-specific antibodies in alcoholic liver cirrhosis



Medicina Clinica 76(4): 154-157



The quantitative alterations of serum immunoglobulins and their relationship with functional liver alterations, and the incidence of non organ-specific antibodies have been studied in patients with alcoholic cirrhosis. The study was performed in 52 patients with alcoholic cirrhosis, and 30 healthy subjects were used as controls. Main findings were: increased serum IgA, IgG, and IgM in cirrhosis (p less than 0.001), increased IgA in liver failure (p less than 0.005), and increased IgM in patients with portal hypertension (p less than 0.001). Regarding non organ-specific antibodies, antinuclear antibodies were found in 28 % of the cases, and anti-smooth muscle antibodies in 9 %. No relationship could be established between antibody positivity and quantitative alterations of the serum immunoglobulins.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 043334299

Download citation: RISBibTeXText

PMID: 6970867


Related references

Serum immunoglobulins and organ non-specific antibodies in diseases of the liver. Scandinavian Journal of Gastroenterology 12(3): 297-304, 1977

Serum prealbumin, transferrin and immunoglobulins in fatty liver, alcoholic cirrhosis and primary biliary cirrhosis. Clinica Chimica Acta; International Journal of Clinical Chemistry 129(3): 279-286, 1983

Antibodies to Escherichia coli in alcoholic and non-alcoholic patients with cirrhosis of the liver or fatty liver. Scandinavian Journal of Gastroenterology 8(5): 433-438, 1973

Time-course changes of serum immunoglobulins (IgA, IgG, IgM) after liver transplantation for alcoholic cirrhosis. Transplant Immunology 11(1): 73-77, 2003

Mortality rate of alcoholic liver disease and risk of hospitalization for alcoholic liver cirrhosis, alcoholic hepatitis and alcoholic liver failure in Australia between 1993 and 2005. Internal Medicine Journal 41(1a): 34-41, 2011

Serum immunoglobulins and five serum proteins in extrahepatic obstructive jaundice and alcoholic cirrhosis. Immunoglobulins and proteins in liver diseases. American Journal of Gastroenterology 56(4): 357-363, 1971

Liver transplantation for alcoholic liver disease: Survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone. Alcoholism Clinical and Experimental Research 17(5): 1102-1106, 1993

Liver transplantation for alcoholic cirrhosis with anti-HCV antibodies. Transplant International 10(4): 289-292, 1997

Reaction pattern of mitochondrial antibodies of primary biliary cirrhosis (PBC) is species specific but not organ specific. Journal of Bioenergetics and Biomembranes 19(3): 239-253, 1987

Liver cirrhosis.An advance on diagnosis and treatment.4.Clinical feature of alcoholic cirrhosis.The comparison with viral liver cirrhosis. Nihon Naika Gakkai Zasshi 80(10): 1587-1591, 1991

The influence of portosystemic shunt operation on immunoglobulins and Escherichia coli antibodies in patients with cirrhosis of the liver. Acta Medica Scandinavica 196(1-2): 109-112, 1974

Fixation of radioactive labeled tissue antibodies in organ homogenates. II. Communication. Organ specific and non-organspecific fixation of antibodies against heterologous kidney- and liver-mitochondria.. Zeitschr Ges Exptl Med 128(6): 548-566, 1957

Coronary Artery Disease in Liver Cirrhosis: A Comparison Between Nash-Related Cirrhosis, Alcoholic Cirrhosis and Cirrhosis Due to Other Etiologies. Gastroenterology 136(5): A-796, 2009

Occurence of antinuclear antibodies, hepatitis B antigens and the significance of immunoglobulins in chronic liver diseases of alcohlic and non-alcoholic etiology. Srpski Arhiv Za Celokupno Lekarstvo 105(7-8): 593-599, 1977

Immunological aspects of hepatic cirrhosis. Levels of immunoglobulins, anti-gamma factor, anti-nuclear antibodies and anti-liver antibodies; study of 152 cases. Minerva Medica 62(33): 1715-1730, 1971