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Immunohistochemical demonstration of IgG in Reed-Sternberg and other cells in Hodgkin's disease

Immunohistochemical demonstration of IgG in Reed-Sternberg and other cells in Hodgkin's disease

Journal of Experimental Medicine 139(5): 1077-1083

Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for IgG but not IgM in Reed-Sternberg cells and faint to strong staining in Hodgkin cells as well. Ultrastructurally the Reed-Sternberg and Hodgkin cells displayed abundant polyribosomes and sparse granular reticulum and appeared to form unexportable IgG on unbound ribosomes.

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Accession: 043334871

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PMID: 4132991

DOI: 10.1084/jem.139.5.1077

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