+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immunopathogenesis of Heymann's nephritis

Immunopathogenesis of Heymann's nephritis

Clinical Immunology and Immunopathology 33(3): 333-338

Renal localization of the C5b-9 membrane attack complex (MAC) in relation to other complement components and immunoglobulins was studied at different stages of Heymann's nephritis and following reimmunization of Lew rats with stage IV disease. Trace amounts of the MAC were found during stages I and IV of disease, whereas during stages II to III, a period of active glomerular and tubular injury, moderate deposits of MAC were observed in glomeruli, periluminal cytoplasm of proximal tubular epithelial cells, and desquamated intraluminal brush border material. Following reimmunization of stage IV animals, a striking increase in the amount of MAC was observed. Moderate to marked deposition of IgG and C3 was also found during stages II and III at sites containing the MAC. Although a slight decrease in detectable IgG was noted during stage IV, a bright, confluent ribbon-like staining pattern was present in reimmunized animals. These data suggest that the MAC is a mediator for acute in situ immune-complex-induced glomerular and tubular cytoplasmic injury, although subsequent proteinuria may persist without continued complement pathway activation and assembly of the MAC.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 043341079

Download citation: RISBibTeXText

PMID: 6388926

DOI: 10.1016/0090-1229(84)90304-0

Related references

Immunopathogenesis of passive heymann nephritis phn. Federation Proceedings 46(3): 734, 1987

Circulatory antigen of Heymann nephritis. III. Presence of the 70-kD circulatory protein in the immune deposits of Heymann nephritis. Clinical and Experimental Immunology 85(3): 469-475, 1991

Circulatory antigen of Heymann nephritis. II. Isolation of a 70,000 MW antigen from normal rat serum which cross-reacts with Heymann nephritis antigen. Immunology 59(3): 451-458, 1986

Detection of glomerular antigens in experimental nephritis (passive Heymann nephritis, serum sickness, and Masugi nephritis)--focal glomerular desensitization and the immuno-deposition elution test. Nihon Jinzo Gakkai Shi 25(8): 961-981, 1983

Monocyte involvement in experimental immune complex nephritis passive heymann nephritis. Experimental Cell Biology 57(2): 98, 1989

Role of autoantibodies against tubular brush border antigens in tubulointerstital nephritis associated with Heymann nephritis. Research Communications in Molecular Pathology & Pharmacology 104(1): 53-62, 1999

Accelerated passive Heymann nephritis in rats as an experimental model for membranous glomerulonephritis and effects of azathioprine and prednisolone on the nephritis. Japanese Journal of Pharmacology 49(1): 101-110, 1989

The duality of Heymann nephritis antigen and immunogenoside--a minute quantity of a membranous nephritis-causing substance contained in somewhat crude nephritogenoside. Arerugi 37(7): 397-403, 1988

FK506, a novel immunosuppressive agent, induces antigen-specific immunotolerance in active Heymann's nephritis and in the autologous phase of Masugi nephritis. Clinical and Experimental Immunology 82(3): 450-455, 1990

Effects of cyclosporin A on experimental nephritis in rats (2): Cyclosporin A suppresses the development of accelerated passive Heymann nephritis. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 103(1): 19-26, 1994

Heymann nephritis. Nihon Rinsho. Japanese Journal of Clinical Medicine 35(6): 2150-2154, 1977

Lymphocyte subsets in Heymann nephritis. Laboratory Investigation; a Journal of Technical Methods and Pathology 51(3): 286-291, 1984

Treatment of heymann nephritis hn by bactobolin ba. Kidney International 37(1): 418, 1990

Investigation of the pathogenesis of heymann nephritis. Clinical Research 33(2 Part 1): 588A, 1985

Possible ligand for the autoantigen gp 600 of heymann nephritis hn. Pediatric Research 23(4 Part 2): 540A, 1988