+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Importance of antiserum and phagocytic cells in the protection of mice against infection by Klebsiella pneumoniae



Importance of antiserum and phagocytic cells in the protection of mice against infection by Klebsiella pneumoniae



Journal of General Microbiology 119(1): 225-229



Rabbit antiserum to Klebsiella pneumoniae showed a powerful protective effect against intramuscular infection in normal mice. No protective effect was observed in mice whose monocytes and polymorphonuclear cells were depleted by X-irradiation. The antiserum had approximately the same protective effect in mice whose macrophages were blocked selectively by carrageenan as in normal mice. It is concluded that antiserum exerted its effect by opsonic function and that opsonized K. pneumoniae were eliminated mainly by polymorphonuclear cells rather than macrophages, at least in an early phase of the infection. these findings were supported by histological examination and observation of intracellular killing in vitro.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 043347131

Download citation: RISBibTeXText

PMID: 6997433

DOI: 10.1099/00221287-119-1-225


Related references

Protection against pulmonary infection with Klebsiella pneumoniae in mice by interferon-gamma through activation of phagocytic cells and stimulation of production of other cytokines. Journal of Medical Microbiology 50(11): 959-964, 2001

Synergistic effect of rabbit specific antiserum and amikacin on the treatment of mice with lethal infection due to Klebsiella pneumoniae. Experientia 37(9): 956-957, 1981

Protection with bacteriophage KØ1 against fatal Klebsiella pneumoniae-induced burn wound infection in mice. Journal of Microbiology Immunology and Infection 42(2): 134-140, 2009

Two Types of Interleukin 17A-Producing γδ T Cells in Protection Against Pulmonary Infection With Klebsiella pneumoniae. Journal of Infectious Diseases 214(11): 1752-1761, 2016

Protection against klebsiella pneumoniae respiratory tract infection of mice and squirrel monkeys saimiri sciureus given kanamycin by aerosol and injection. American Journal of Veterinary Research 40(9): 1231-1235, 1979

Studies of BAL cells during the airborne Klebsiella pneumoniae infection in immunocompromised mice. Zhonghua Jiehe He Huxi Zazhi 15(3): 161-162, 191, 1992

Studies of bronchoalveolar lavage cells during the airborne Klebsiella pneumoniae infection in immunocompromised mice. Zhonghua Jie he He Hu Xi Za Zhi 15(3): 161-2 191, 1992

Lipocalin-2 from both myeloid cells and the epithelium combats Klebsiella pneumoniae lung infection in mice. Blood 129(20): 2813-2817, 2017

Lipid-based signaling modulates DNA repair response and survival against Klebsiella pneumoniae infection in host cells and in mice. American Journal of Respiratory Cell and Molecular Biology 49(5): 798-807, 2013

Risk Factors for Carbapenem-resistant Klebsiella pneumoniae Infection and Mortality of Klebsiella pneumoniae Infection. Chinese Medical Journal 131(1): 56-62, 2018

Emergence of resistant Klebsiella pneumoniae in the intestinal tract during successful treatment of Klebsiella pneumoniae lung infection in rats. Antimicrobial Agents and ChemoTherapy 54(7): 2960-2964, 2010

Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniae. Open Forum Infectious Diseases 5(4): Ofy054, 2018

Murine monoclonal antibodies to klebsiella pneumoniae protect against lethal endotoxemia and experimental infection with capsulated klebsiella pneumoniae. Infection & Immunity 58(9): 2828-2833, 1990

Advances in risk factors of Klebsiella pneumoniae carbapenemases-producing Klebsiella pneumoniae infection or colonization and its treatment strategies. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 29(12): 1148-1152, 2017

Outbreak of infection with Klebsiella pneumoniae sequence type 258 producing Klebsiella pneumoniae Carbapenemase 3 in an intensive care unit in Italy. Journal of Clinical Microbiology 48(4): 1506-1507, 2010