+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

In vitro activity of meropenem and seven other beta-lactam antibiotics against K.pneumoniae and enterobacteriaceae producing beta-lactamases with extended spectrum



In vitro activity of meropenem and seven other beta-lactam antibiotics against K.pneumoniae and enterobacteriaceae producing beta-lactamases with extended spectrum



Pathologie-Biologie 42(5): 365-368



Meropenem is a broad antibacterial spectrum carbapenem with a good activity on betalactam resistant Gram-negative bacilli. 120 non repetitive strains isolated from clinical samples from 1989 to 1992 were selected: 60 K. pneumoniae, 7 E. coli, 2 E. aerogenes and 1 S. marcescens with extended spectrum betalactamases (23 CTX-1, 18 SHV-2, 5 SHV-3, 16 SHV-4, 4 SHV-5, 3 CTX-1 + SHV-4, 1 CAZ-1), 10 K. pneumoniae with broad spectrum TEM-1 enzyme, and 40 K. pneumoniae with only SHV-1 chromosomal betalactamase. Determination of Minimal inhibitory concentrations (MIC) was done by agar dilution method for meropenem and 7 other betalactams (amoxicillin + clavulanic acid 2 mg/l, piperacillin + tazobactam 4 mg/l, cefoxitin, cefotetan, cefotaxime, ceftazidime, imipenem). All antibiotics except amoxicillin + clavulanic acid are active against strains with constitutive penicillinase. For strains with TEM-1 penicillinase, cephamycins, third generation cephalosporins and carbapenems are active. For strains with different extended spectrum betalactamases only cephamycins and carbapenems are efficious. There is no difference according to the period of isolation: 1989-90 or 1991-92. Meropenem has the best in vitro activity (MIC50 = 0.03 mg/l) for all strains independently of the nature of betalactamase.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 043358519

Download citation: RISBibTeXText

PMID: 7824297


Related references

An inoculum effect with beta-lactam antibiotics against enterobacteriaceae producing extended-spectrum beta-lactamases. Journal of Antimicrobial Chemotherapy 44(Suppl. A): 153, 1999

In vitro activity of beta-lactam and non-beta-lactam antibiotics in extended-spectrum beta-lactamase-producing clinical isolates of Escherichia coli. Diagnostic Microbiology and Infectious Disease 54(2): 135-139, 2006

Bactericidal activity of oral beta-lactam antibiotics in plasma and urine versus isogenic Escherichia coli strains producing broad- and extended-spectrum beta-lactamases. International Journal of Antimicrobial Agents 25(6): 479-487, 2005

Evaluation of six beta-lactam substrates for the detection of extended spectrum beta-lactamases producing Klebsiella pneumoniae strains from Brazil. Abstracts of the General Meeting of the American Society for Microbiology 97: 207, 1997

Activities of beta-lactam antibiotics against Escherichia coli strains producing extended-spectrum beta-lactamases. Antimicrobial Agents and ChemoTherapy 34(5): 858-862, 1990

In vitro activity of fourth generation cephalosporins against enterobacteriaceae producing extended-spectrum beta-lactamases. Journal of ChemoTherapy 8(Suppl. 2): 57-62, 1996

Resistance of Klebsiella pneumoniae strains producing and not producing ESBL (extended-spectrum beta-lactamase) type enzymes to selected non-beta-lactam antibiotics. Medical Science Monitor 8(3): Br100, 2002

Ceftibuten and bactericidal kinetics. Comparative in vitro activity against Enterobacteriaceae producing extended spectrum beta-lactamases. Diagnostic Microbiology and Infectious Disease 14(1): 89-92, 1991

Effect of porin loss on the activity of tigecycline against Klebsiella pneumoniae producing extended-spectrum beta-lactamases or plasmid-mediated AmpC-type beta-lactamases. Diagnostic Microbiology and Infectious Disease 61(3): 343-345, 2008

Prevalence of the genes encoding extended-spectrum beta-lactamases, in Escherichia coli resistant to beta-lactam and non-beta-lactam antibiotics. Annals of Tropical Medicine and Parasitology 99(4): 413-417, 2005

Prevalence of gene(s) encoding extended spectrum beta lactamases (ESBL) in Escherichia coli resistant to beta lactam and non-beta lactam antibiotics. 2005

Activity of NXL104 in combination with beta-lactams against genetically characterized Escherichia coli and Klebsiella pneumoniae isolates producing class A extended-spectrum beta-lactamases and class C beta-lactamases. Antimicrobial Agents and ChemoTherapy 55(5): 2434-2437, 2011

In vitro activity of meropenem and seven other betalactam antibiotics against K. pneumoniae and enterobacteriaceae with extended spectrum betalactamases. Pathologie Biologie 42(5): 365-368, 1994

Beta lactam antibiotics activity against escherichia coli omp f negative harboring extended spectrum beta lactamases. Program & Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 31: 117, 1991

In vitro activity of the new penem men 10700 against clinical isolates of Enterobacteriaceae producing extended-spectrum beta-lactamases or inducible cephalosporinases. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 39: 295, 1999