+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Incidence of herpes zoster in pediatricians and history of reexposure to varicella-zoster virus in patients with herpes zoster

Incidence of herpes zoster in pediatricians and history of reexposure to varicella-zoster virus in patients with herpes zoster

Kansenshogaku Zasshi. Journal of the Japanese Association for Infectious Diseases 69(8): 908-912

We found that pediatricians have enhanced specific cellular immunity to varicella-zoster virus (VZV) compared with the general population, which may be due to reexposure to VZV from children with chickenpox. There have been some reported that the varicella vaccine enhance the specific cellular immunity. To estimate the efficacy of varicella vaccine for protection against herpes zoster in the elderly, we investigated the incidence of herpes zoster in 500 pediatricians and family practitioners with their fifties and sixties, and history of reexposure to VZV in 61 patients with herpes zoster by questionnaires retrospectively. Thirty-four of 352 pediatricians had a past history of herpes zoster. The incidence per 100,000 person-years of herpes zoster was 65.2 in those in their fifties and 158.2 in those in their sixties, which are 1/2 to 1/8 of other reports regarding the general population. Among 61 immunocompetent patients with herpes zoster, only 4 patients (6.6%) had the chance for reexpose to VZV before their herpes zoster. Only 7 (17.5%) of the 40 patients older than 50 years of age lived with their children less than 14 years of age. Twenty-three (57.5%) of them lived without their children and grandchildren. They are thought to be less chance to reexpose to VZV through children. We may think that the booster effect by reexposure to VZV plays an important role to prevent herpes zoster. Therefore, we can speculate that the varicella vaccine may protect against herpes zoster in the elderly by the enhanced specific cellular immunity due to the booster effect.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 043369672

Download citation: RISBibTeXText

PMID: 7594784

DOI: 10.11150/kansenshogakuzasshi1970.69.908

Related references

Incidence of herpes zoster in pediatricians and family practitioners Estimation of efficacy of varicella vaccine for protection against herpes zoster in the elderly. Kawasaki Medical Journal 20(3-4): 99-102, 1994 ( ), 1995

Herpes zoster in the first year of life following postnatal exposure to varicella-zoster virus: four case reports and a review of infantile herpes zoster. Archives of Dermatology 140(10): 1268-1272, 2004

Incidence of serum antibody titers against varicella zoster virus in Japanese patients with herpes zoster. Journal of Dermatology 44(6): 656-659, 2017

Subclinical varicella-zoster virus viremia, herpes zoster, and T lymphocyte immunity to varicella-zoster viral antigens after bone marrow transplantation. Journal of Infectious Diseases 165(1): 119-126, 1992

Herpes zoster in a 2-month-old infant, intragestational varicella and reexposure to exogenous varicella zoster. Anales de Pediatria 60(3): 282-283, 2004

Incidence, risk factors, and implemented prophylaxis of varicella zoster virus infection, including complicated varicella zoster virus and herpes simplex virus infections, in lenalidomide-treated multiple myeloma patients. Annals of Hematology 93(3): 479-484, 2014

Association of reduced CD4 T cell responses specific to varicella zoster virus with high incidence of herpes zoster in patients with systemic lupus erythematosus. Journal of Rheumatology 31(11): 2151-2155, 2004

Varicella-zoster virus-specific enzyme-linked immunospot assay responses and zoster-associated pain in herpes zoster subjects. Clinical and Vaccine Immunology 19(9): 1411-1415, 2012

Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine. Journal of Infectious Diseases 200(7): 1068-1077, 2009

Increased incidence of herpes zoster in patients on renal replacement therapy cannot be explained by intrinsic defects of cellular or humoral immunity to varicella-zoster virus. Antiviral Research 158: 206-212, 2018

Acute pain and postherpetic neuralgia related to Varicella zoster virus reactivation: Comparison between typical herpes zoster and zoster sine herpete. Journal of Medical Virology 91(2): 287-295, 2019

Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. British Journal of Ophthalmology 92(4): 505-508, 2008

Risk of Herpes Zoster and Disseminated Varicella Zoster in Patients Taking Immunosuppressant Drugs at the Time of Zoster Vaccination. Mayo Clinic Proceedings 90(7): 865-873, 2015

Incidence of herpes zoster and seroprevalence of varicella-zoster virus in young adults of South Korea. International Journal of Infectious Diseases 12(3): 245-247, 2008

Varicella zoster virus: natural history and current therapies of varicella and herpes zoster. Herpes 14(Suppl. 2): 25-29, 2007