EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Increased norepinephrine release during sympathetic nerve stimulation and its inhibition by adenosine in the isolated perfused kidney of spontaneously hypertensive rats



Increased norepinephrine release during sympathetic nerve stimulation and its inhibition by adenosine in the isolated perfused kidney of spontaneously hypertensive rats



Clinical and Experimental Hypertension. Part A, Theory and Practice 5(1): 41-48



The present study was performed to measure norepinephrine release during sympathetic nerve stimulation and determine the inhibitory action of adenosine on stimulus-induced release of norepinephrine in the isolated perfused kidney of WKY and SHR. Norepinephrine release during periarterial nerve stimulation was measured as total 3H-overflow since greater than 75% of total 3H-overflow was 3H-norepinephrine in both the WKY and SHR. A significantly greater increase in 3H-norepinephrine overflow was observed during periarterial nerve stimulation in SHR in comparison with WKY. Adenosine (0.3, 1.0, 3.0 and 10.0 micrograms/ml) produced dose-dependent inhibition of 3H-norepinephrine overflow elicited by periarterial nerve stimulation. However, the effect of adenosine on transmitter release was more pronounced in the SHR in that the threshold dose required to cause inhibition of stimulus-induced release of 3H-norepinephrine was smaller in the SHR. These results demonstrate that while norepinephrine release during sympathetic nerve stimulation is greater in the SHR, this finding can not be explained on the basis of a decrease in the presynaptic inhibitory action of adenosine. Therefore, the mechanism responsible for the increased release of norepinephrine in the SHR remains to be determined.

(PDF emailed within 0-6 h: $19.90)

Accession: 043376040

Download citation: RISBibTeXText

PMID: 6831740

DOI: 10.3109/10641968309048809



Related references

Altered adenosine modulated norepinephrine release from peripheral sympathetic nerve terminals in spontaneously hypertensive rats. Japanese Journal of Pharmacology 52(SUPPL 2): 115P, 1990

Diminished prostaglandin-mediated inhibition of norepinephrine release from the sympathetic nerve endings in spontaneously hypertensive rats. Clinical and Experimental Hypertension. Part A, Theory and Practice 9(10): 1601-1614, 1987

Facilitation of norepinephrine release by beta adrenoceptor agonists during sympathetic nerve stimulation in the isolated perfused rat kidney. Federation Proceedings 41(4): ABSTRACT 4589, 1982

Release of prostaglandins I2 and E2 from the perfused mesenteric arterial bed of normotensive and hypertensive rats. Effects of sympathetic nerve stimulation and norepinephrine administration. Prostaglandins 23(4): 543-549, 1982

Increased responsiveness to renal nerve stimulation in isolated perfused kidneys from young spontaneously hypertensive rats. Circulation Supplement 56(4): III-161, 1977

Increased presynaptic alpha adrenoceptor mediated regulation of noradrenaline release in the isolated perfused kidney of spontaneously hypertensive rats. Clinical Science (London) 63(SUPPL 8): 309S-312S, 1982

Exaggerated response to electrical nerve stimulation of angiotensin II release in isolated perfused hind legs of spontaneously hypertensive rats. Clinical and Experimental Hypertension. Part A, Theory and Practice 13(5): 839-847, 1991

Release of adenosine-like material from isolated perfused dog adipose tissue following sympathetic nerve stimulation and its inhibition by adrenergic alpha-receptor blockade. Acta Physiologica Scandinavica 96(3): 122-130, 1976

Release of prostaglandin i 2 and prostaglandin e 2 from the perfused mesenteric arterial bed of normotensive and hypertensive rats effects of sympathetic nerve stimulation and norepinephrine administration. Prostaglandins 23(4): 543-550, 1982

Differences in responses to norepinephrine and adenosine triphosphate in isolated, perfused mesenteric vascular beds between normotensive and spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology 32(5): 807-818, 1998

Effects of edrf on norepinephrine release from sympathetic nerve terminals in mesenteric artery of spontaneously hypertensive rats. Hypertension (Dallas) 18(3): 403, 1991

Atrial natriuretic factor inhibits norepinephrine release evoked by sympathetic nerve stimulation in isolated perfused rat mesenteric arteries. European Journal of Pharmacology 123(3): 459-461, 1986

Alteration of presynaptic alpha 2-mediated inhibition of norepinephrine release in perfused mesenteric arteries of young and adult spontaneously hypertensive rats. Journal of Hypertension. Supplement 2(3): S95-S97, 1984

The direct and amplifying effects of serotonin are increased with age in the isolated perfused kidney of Wistar and spontaneously hypertensive rats. Naunyn-Schmiedeberg's Archives of Pharmacology 334(4): 327-332, 1986

Effects of indomethacin on angiotensin ii mediated modulation of endogenous norepinephrine release from the isolated perfused mesenteric vasculature of wistar kyoto and spontaneously hypertensive rats. FASEB Journal 4(4): A1003, 1990