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Induction of a delayed cyclic AMP-sensitive sodium current in mollusk neurons by G-protein activators



Induction of a delayed cyclic AMP-sensitive sodium current in mollusk neurons by G-protein activators



Biofizika 40(1): 110-114



The experiments have been carried out with isolated Helix pomatia neurons by the method of two-microelectrode voltage clamping. cAMP and the activators of G-proteins, F-, GTP and Gpp (NH)p, were injected via ionophoresis into the neurons using a seven-channel microelectrode. It is found that the G-protein activators induce both input and output currents in the neurons where slow sodium current can be activated by cAMP. The input G-activated and cAMP-activated currents are similar in kinetics, voltage dependence and reverse voltage. The G- and cAMP-responses are not additive. The results obtained allow the conclusion that the G-protein activators can stimulate the slow cAMP-sensitive sodium channels.

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Accession: 043385307

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PMID: 7703266


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