+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Induction of a delayed cyclic AMP-sensitive sodium current in mollusk neurons by G-protein activators

Induction of a delayed cyclic AMP-sensitive sodium current in mollusk neurons by G-protein activators

Biofizika 40(1): 110-114

The experiments have been carried out with isolated Helix pomatia neurons by the method of two-microelectrode voltage clamping. cAMP and the activators of G-proteins, F-, GTP and Gpp (NH)p, were injected via ionophoresis into the neurons using a seven-channel microelectrode. It is found that the G-protein activators induce both input and output currents in the neurons where slow sodium current can be activated by cAMP. The input G-activated and cAMP-activated currents are similar in kinetics, voltage dependence and reverse voltage. The G- and cAMP-responses are not additive. The results obtained allow the conclusion that the G-protein activators can stimulate the slow cAMP-sensitive sodium channels.

(PDF emailed within 1 workday: $29.90)

Accession: 043385307

Download citation: RISBibTeXText

PMID: 7703266

Related references

Induction by activators of the G-proteins of the slow cAMP-sensitive sodium current in molluscan neurons. Biophysics (English Translation of Biofizika) 40(1): 111-115, 1995

Independent effects of ph i calcium ion and phosphodiesterase on the cyclic amp gated sodium ion current in neurons of the mollusk pleurobranchaea. Society for Neuroscience Abstracts 16(2): 1300, 1990

Activators of protein kinase C selectively enhance inactivation of a calcium current component of cultured sensory neurons in a pertussis toxin-sensitive manner. Journal of Neurophysiology 61(6): 1259-1269, 1989

Stimulation of sodium current by cyclic AMP is mediated through protein phosphorylation in Euhadra neurons. Experientia 44(11-12): 996-998, 1988

Cyclic GTP imitates the potentiating effect of the nootrope vinpocetine on the high-threshold A-current in mollusk neurons. Neuroscience and Behavioral Physiology 29(6): 671-675, 2000

Mechanisms of the inhibitory effect of cyclic adenosine monophosphate on calcium current in intact mollusk neurons. Neurophysiology 22(1): 45-50, 1990

The mechanisms of the inhibiting action of cyclic adenosine monophosphate on the calcium current of intact mollusk neurons. Neirofiziologiia 22(1): 54-61, 1990

Cyclic GMP mimicks potentiation effect of the nootropic agent vinpocetine on the high threshold A-current in the mollusk neurons. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 84(8): 741-746, 1998

Characteristics of the potential dependent sodium pump current of the membrane of mollusk giant neurons. Neirofiziologiya 7(4): 428-433, 1975

Synaptic correlates of a sodium dependent current induced by a cyclic nucleotide cyclic amp in aplysia neurons. Journal of Physiology (Cambridge) 377: 34P, 1986

Bulleyaconitine A preferably reduces tetrodotoxin-sensitive sodium current in uninjured dorsal root ganglion neurons of neuropathic rats probably via inhibition of protein kinase C. Pain 158(11): 2169-2180, 2017

Effects of aluminum chloride on sodium current, transient outward potassium current and delayed rectifier potassium current in acutely isolated rat hippocampal CA1 neurons. Food and Chemical Toxicology 42(9): 1453-1462, 2004

Lidocaine slows repriming of ttx resistant sodium current of sensory neurons more than ttx sensitive current. Neurology 39(3 SUPPL 1): 328, 1989

Cyclic amp dependence of a delayed potassium current in bullfrog sensory neurons. Japanese Journal of Physiology 40(SUPPL): S110, 1990

Activators of protein kinase C enhance cyclic AMP accumulation in cerebral cortical and diencephalic neurons in primary culture. Journal of Neuroscience Research 20(2): 195-201, 1988