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Induction of alkaline phosphatase activity by dibutyryl adenosine 3':5'-cyclic monophosphate in aneuploid rat liver cells

Nose, K.; Katsuta, H.

Experimental Cell Research 87(1): 8-14

1974

ISSN/ISBN: 0014-4827
PMID: 4366851
DOI: 10.1016/0014-4827(74)90520-5
Accession: 043385449
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Alkaline phosphatase activity (ALP) in cultured rat liver cells, strain JTC-25 · P5, was found to increase more than tenfold when cells were incubated in the presence of dibutyryl cyclic adenosine 3′:5′-monophosphate (But2c AMP) and theophylline. Among six subclones of this cell strain, four were able to be induced for Alp activity, but two were not. However, the incorporation of 3H-But2c Amp into cells did not differ from each other significantly. The cellular growth was apparently inhibited in the presence of theophylline and But2c AMP, and extensive cytoplasmic elongation was observed in both types of subclones. The increase of Alp activity appeared to depend upon the de novo protein synthesis, since cycloheximide inhibited the induction.

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