Induction of forestomach hyperplasia by crude butylated hydroxyanisole, a mixture of 3-tert and 2-tert isomers, in Syrian golden hamsters is due to 3-tert-butylated hydroxyanisole

Ito, N.; Hirose, M.; Kurata, Y.; Ikawa, E.; Mera, Y.; Fukushima, S.

Gan 75(6): 471-474


ISSN/ISBN: 0016-450X
PMID: 6468835
Accession: 043386313

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Male Syrian golden hamsters were given 1.0% 2-tert- or 3-tert-butylated hydroxyanisole (BHA) or crude BHA for 1 to 4 weeks. The incidence of severe hyperplasia induced in the forestomach was high in the hamsters given 3-tert-BHA or crude BHA for 2 weeks or more, but was almost at the control level in those given 2-tert-BHA. Thus, the 3-tert isomer would appear to be responsible for the tumorigenicity of crude BHA.