Inhibition of histamine-sensitive adenylate cyclase from guinea pig fundic gastric mucosa by arachidonic acid and by an analog of prostaglandin endoperoxide PGH2

Dozois, R.R.; Madson, T.H.; Dousa, T.P.

Digestive Diseases and Sciences 25(4): 273-278

1980


ISSN/ISBN: 0163-2116
PMID: 7389526
DOI: 10.1007/bf01308517
Accession: 043412887

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Abstract
The effects of prostaglandin precursors, namely an analog of prostaglandin endoperoxide PGH2 [(15S)-hydroxy-9 alpha,11 alpha-(epoxymethano)prosta-5,13-dienoic acid] and arachidonic acid, were assessed on gastric adenylate cyclase activity from cell-free preparations of guinea pig fundic mucosa. The two precursors were tested against basal adenylate cyclase activity and that simulated by histamine (10(-4) M), by PGE2(10(-4) M), by 5

Inhibition of histamine-sensitive adenylate cyclase from guinea pig fundic gastric mucosa by arachidonic acid and by an analog of prostaglandin endoperoxide PGH2