Inhibition of vitamin K2 and carotenoid synthesis in Staphylococcus aureus by diphenylamine

Hammond, R.K.; White, D.C.

Journal of Bacteriology 103(3): 611-615


ISSN/ISBN: 0021-9193
PMID: 4319835
Accession: 043416441

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Diphenylamine at concentrations which did not effect the growth rate inhibited the synthesis of vitamin K(2) in both anaerobic and aerobic cultures by about 50%. At this concentration, diphenylamine inhibited the synthesis of the cyclic carotenoids delta-carotene and the rubixanthins 25 to 35% anaerobically and 60 to 90% aerobically. The inhibition of synthesis of cyclic carotenoids and vitamin K(2) by diphenylamine had no detectable effect on the formation of the membrane-bound electron transport system.