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Instability and variable toxicity of HBP-Tx, a toxin in the cyanobacterium Microcystis aeruginosa

Instability and variable toxicity of HBP-Tx, a toxin in the cyanobacterium Microcystis aeruginosa

Toxicon 22(1): 107-114

It was found that autoxidative degradation is responsible for the inactivation of the unstable Microcystis toxin HBP-Tx. The purified toxin was similar in its properties to the "fast-death-factor" in Microcystis, described as a cyclic peptide in the literature. The apparent presence of an entirely different toxin was simulated by the partially inactivated HBP-Tx. A number of associated fluorescent compounds were identified as the non-toxic degradation products of the toxin. As a consequence, as established method for the detection of other algal toxins was applied. This chemical assay, which uses fluorescent measurement of the oxidized toxin in the cyanobacterium Aphanizomenon flos-aquae, was applicable for HBP-Tx after the removal of interfering degradation products of the toxin. The results obtained with Microcystis toxin HBP-Tx do not confirm suggestions concerning the structure of the "fast-death-factor".

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Accession: 043423000

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PMID: 6426092

DOI: 10.1016/0041-0101(84)90143-0

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