+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Intensive treatment of AIDS-related non-Hodgkin's lymphomas with the MACOP-B protocol

Intensive treatment of AIDS-related non-Hodgkin's lymphomas with the MACOP-B protocol

European Journal of Haematology 54(2): 73-77

The usefulness of intensive chemotherapy with the MACOP-B protocol was evaluated in 8 patients with AIDS-related non-Hodgkin's lymphoma (NHL). Four patients had a prior AIDS diagnosis. The median CD4+ lymphocyte count was 0.079 cells x 10(9)/l (range 0.016-0.330). All patients responded to treatment. Four patients finished chemotherapy, all with complete remission, while another 3 patients deteriorated prior to finishing treatment and died. The median survival was 4 months (range 1 to 86 months). Major causes of the poor outcome were AIDS-related opportunistic infections and meningeal CNS involvement by NHL developing during or after chemotherapy. Patients with AIDS-related NHL usually do not appear to benefit from treatment with MACOP-B protocol. Advanced immunodeficiency is associated with poor tolerance to treatment and inability to finish this chemotherapy protocol. MACOP-B chemotherapy does not prevent meningeal spread of lymphoma in spite of using repeatedly systemic methotrexate crossing the blood-brain barrier. CNS prophylaxis with repeated application of intrathecal methotrexate may lower the risk of meningeal spread of lymphoma, which developed in 1 of 5 patients given CNS prophylaxis as compared to 2 of 3 patients without CNS prophylaxis.

(PDF emailed within 0-6 h: $19.90)

Accession: 043428591

Download citation: RISBibTeXText

PMID: 7535244

DOI: 10.1111/j.1600-0609.1995.tb01771.x

Related references

Intensive treatment of AIDS-related non-Hodgkin lymphomas with the MACOP-B protocol Report on eight cases. Program & Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 33(0): 427, 1993

The treatment of large-cell non-Hodgkin's lymphomas with the MACOP-B protocol. Medicina Clinica 97(14): 521-525, 1991

Treatment of high-grade non-Hodgkin's lymphomas with short intensive chemotherapy (MACOP-B). Bulletin du Cancer (Paris) 80(9): 808-815, 1993

Value of MACOP B polychemotherapy for malignant non-Hodgkin's lymphomas in AIDS infected patients. Presse Medicale 21(6): 269, 1992

MACOP-B vs F-MACHOP in the treatment of high-grade non-Hodgkin's lymphomas. Leukemia 5 Suppl 1: 74-78, 1991

MACOP-B vs F-MACHOP regimen in the treatment of high-grade non-Hodgkin's lymphomas. Leukemia and Lymphoma 16(5-6): 457-463, 1995

MACOP-B treatment for intermediate and high-grade non-Hodgkin's lymphomas at diagnosis and in relapse. Haematologica 75(2): 149-154, 1990

Long-term results with MACOP-B in the treatment of aggressive non-Hodgkin's lymphomas. The experience in Brazil. American Journal of Clinical Oncology 17(4): 323-327, 1994

Treatment results with an aggressive chemotherapeutic regimen (MACOP-B) for intermediate- and some high-grade non-Hodgkin's lymphomas. Journal of Clinical Oncology 8(1): 94-102, 1990

AIDS-related non-Hodgkin's lymphomas: From pathology and molecular pathogenesis to treatment. Human Pathology 33(4): 392-404, 2002

Human herpesvirus 6 in non-AIDS related Hodgkin's and non-Hodgkin's lymphomas. Leukemia 6 Suppl 3: 46s-48s, 1992

Treatment of medium and highly malignant non-Hodgkin's lymphoma with combined chemotherapy using methotrexate, adriamycin, cyclophosphamide, vincristine, prednisone and bleomycin (protocol MACOP-B). Vnitrni Lekarstvi 35(12): 1177-1182, 1989

Different Incidence of Novel Glycosylation Sites in Ig Variable Regions of Immunodeficiency-Related Non-Hodgkin Lymphomas Distinguishes between Subsets of AIDS-Lymphomas and Post-Transplantation Lymphoproliferative Disorders. Blood 100(11): Abstract No 2232, November 16, 2002

MACOP-B and VACOP-B in diffuse large cell lymphomas and MOPP/ABV in Hodgkin's disease. Annals of Oncology 2 Suppl 1: 17-23, 1991

Treatment of aggressive primary lymphomas of the digestive system by intensive chemotherapy. Experience of the Study Group on Lymphomas in Adults with the LNH-84 protocol. Annales de Gastroenterologie et d'Hepatologie 28(4): 205-208, 1992