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Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components



Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components



Journal of Experimental Medicine 128(5): 1049-1057



Large amounts of each C'3, C'5, C'6, C'7, C'8, and C'9 were consumed when guinea pig serum was incubated with endotoxic lipopolysaccharide, zymosan, or preformed immune complexes. Since these C' components subserve several of the biological activities which follow the injection of endotoxins into experimental animals, these experiments support the hypothesis that certain biological effects induced by endotoxins may be mediated via the C' system, and may account for some of the known similarity in the reactivities evoked by endotoxins and immune complexes in vivo.

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Accession: 043434220

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PMID: 4176223

DOI: 10.1084/jem.128.5.1049


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