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Interactions of the complement system with endotoxic lipopolysaccharides in immunoglobulin-deficient sera



Interactions of the complement system with endotoxic lipopolysaccharides in immunoglobulin-deficient sera



Journal of Experimental Medicine 131(4): 817-831



Bacterial lipopolysaccharides (LPS) derived from a variety of organisms effectively induced C consumption in humans, bovines, and porcines with developmental agammaglobulinemia; birds with experimental agammaglobulinemia; and humans with agammaglobulinemia syndromes. This interaction proceeded even in precolostral piglet sera which contained less than 2.5 x 10(-6) mg/ml gamma globulin, and led to generation of neutrophil chemotactic factor and anaphylatoxin in these sera. Hence, the LPS-C interaction can proceed in sera markedly deficient in immunoglobulin. The question of whether immunoglobulins can be bypassed in the LPS-C interaction, or whether they are regularly utilized in a way so efficient that their participation is masked, was considered.

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Accession: 043434222

Download citation: RISBibTeXText

PMID: 4193936

DOI: 10.1084/jem.131.4.817


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