Intergeneric cosynthesis of penicillin by strains of Penicillium chrysogenum, P. chrysogenum/notatum and Aspergillus nidulans
Makins, J.F.; Allsop, A.; Holt, G.
Journal of General Microbiology 122(2): 339-343
1981
ISSN/ISBN: 0022-1287
PMID: 6798163
DOI: 10.1099/00221287-122-2-339
Accession: 043436965
A number of mutants impaired in penicillin production have previously been isolated from Penicillium chrysogenum and Aspergillus nidulans. During cofermentation of osmotically fragile mycelia derived from these strains, in the presence of inhibitors of cell wall regeneration, intergeneric cosynthesis has been demonstrated between mutants which are probably impaired in different parts of th penicillin biosynthetic pathway.