EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Methyl-tertiary-butyl ether (MTBE)--a gasoline additive--causes testicular and lymphohaematopoietic cancers in rats


Methyl-tertiary-butyl ether (MTBE)--a gasoline additive--causes testicular and lymphohaematopoietic cancers in rats



Toxicology and Industrial Health 11(2): 119-149



ISSN/ISBN: 0748-2337

PMID: 7491630

DOI: 10.1177/074823379501100202

In the framework of a series of experiments conducted to evaluate the carcinogenic effects of oxygenated gasoline additives, MTBE was analyzed in an oral lifetime carcinogenicity study using 8-week-old male and female Sprague-Dawley rats. These experiments were part of a large research project on gasoline carcinogenicity performed at the Bentivoglio (BT) Castle Cancer Research Center of the Ramazzini Foundation and of the Bologna Institute of Oncology, MTBE, dissolved in oil, was administered by stomach tube at the doses of 1000, 250, or 0 mg/kg b.w., once daily, four days weekly, for 104 weeks. The animals were maintained until natural death. The last animal died 166 weeks after the start of the experiment, i.e., at 174 weeks of age. Under the tested experimental conditions, MTBE was shown to cause an increase in Leydig interstitial cell tumors of the testes and a dose-related increase in lymphomas and leukemias in female rats.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 043645523

Download citation: RISBibTeXText

Related references

The impact of the gasoline additive methyl tertiary-butyl ether (MTBE) on groundwater; a German perspective. IAHS-AISH Publication 275: 567-570, 2002

Effect of methyl tertiary butyl ether (MTBE) as a gasoline additive on engine performance and exhaust emissions. Fuel Science and Technology International 11(10): 1331-1343, 1993

Hazardous pollutant: gasoline containing methyl tertiary-butyl ether (MTBE). International Journal of Occupational and Environmental Health 4(2): 134-135, 1998

Pollution by gasoline containing hazardous methyl tertiary butyl ether (MTBE). Archives of Environmental Health 53(4): 245-246, 1998

Impact of the gasoline oxygenate methyl-tertiary-butyl-ether (MTBE) on groundwater. Pages 307-308:, 2000

Reports of illness attributed to the use of methyl tertiary butyl ether (MTBE) in gasoline. Archives of Environmental Health 50: 5-6, 1995

Health effects of methyl tertiary butyl ether (MTBE) in gasoline in Alaska. Alaska Medicine 37(3): 101-3 119, 1995

Evaluation of fate and transport of methyl tertiary butyl ether (MTBE) in gasoline following a small spill. Proceedings of the Petroleum Hydrocarbons and Organic Chemicals in Ground Water: Prevention, Detection and Remediation Conference 2000: 229-246, 1999

Interactive effects of methyl tertiary-butyl ether (MTBE) and tertiary-amyl methyl ether (TAME), ethanol and some drugs: Triglyceridemia, liver toxicity and induction of CYP (2E1, 2B1) and phase II enzymes in female Wistar rats. Environmental Toxicology and Pharmacology 23(1): 64-72, 2007

Subchronic oral methyl tertiary butyl ether (MTBE) exposure in male Sprague-Dawley rats and effects on health of MTBE exposed workers. Journal of Occupational Health 41(1): 33-38, 1999

Projection of health benefits from ambient ozone reduction related to the use of methyl tertiary butyl ether (MTBE) in the reformulated gasoline program. Risk Analysis: An Official Publication of the Society for Risk Analysis 17(6): 693-704, 1997

Effects of gasoline formulation on methyl tert-butyl ether (MTBE) contamination in private wells near gasoline stations. Environmental Science and Technology 35(6): 1050-1053, 2001

Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CDE-1 mice in F-344 rats. Journal of Applied Toxicology 17(Suppl 1): S45-S55, 1997

Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats. Journal of Applied Toxicology: Jat 17(Suppl): S45-S55, 1997

Two-generation reproductive toxicity study of methyl tertiary-butyl ether (MTBE) in rats. Journal of Applied Toxicology: Jat 17(Suppl): S13-S19, 1997