+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Monocyte-mediated antibody-dependent cell-mediated cytotoxicity and spontaneous cytotoxicity in normals and cancer patients as assayed by human erythrocyte lysis



Monocyte-mediated antibody-dependent cell-mediated cytotoxicity and spontaneous cytotoxicity in normals and cancer patients as assayed by human erythrocyte lysis



Cancer Research 43(9): 4504-4510



The monocyte-macrophage system has long been recognized as a necessary accessory to the immune response. Recently, however, monocyte-macrophages have been shown to be important effectors of cell-mediated cellular cytotoxicity (both antibody dependent and antibody independent). In this study, monocyte-mediated cellular cytotoxicity of both types was assessed on 51Cr-labeled human erythrocytes (type B+) using autologous and standardized AB serum, and monocytes from 57 normal controls, 16 women with benign breast disease, and 175 patients with cancers of the breast (44 patients), colorectum (46 patients), head and neck (33 patients), lung (13 patients), and melanoma (39 patients). Although results were variable, many of the patients had depressed antibody-dependent cellular cytotoxicity suggesting decreased ability of their monocyte-macrophage to lyse the sensitized erythrocytes. Enhanced antibody-dependent cellular cytotoxicity was observed in patients with localized colorectal cancer, but this effect was reversed in patients with advanced disease. Serum factors did not significantly affect responses in most cases. The clinical relevance of this assay remains to be determined.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 043678365

Download citation: RISBibTeXText

PMID: 6871879


Related references

Antibody dependent cell mediated cytotoxicity toward human o positive red cells coated with anti d antibody comparison between lymphocyte and monocyte antibody dependent cell mediated cytotoxicity activity. Acta Medica Okayama 39(2): 77-90, 1985

Lysis of dengue virus-infected cells by natural cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity. Journal of Virology 52(1): 223-230, 1984

Inhibition of spontaneous but not antibody-dependent cell-mediated cytotoxicity by simple sugars: evidence that endogenous lectins may mediate spontaneous cell-mediated cytotoxicity. Immunology 44(1): 143-152, 1981

Spontaneous lymphocyte-mediated cytotoxicity and antibody-dependent cell cytotoxicity of human effector cells. Folia Haematologica 110(6): 831-842, 1983

Antibody-dependent cell-mediated cytotoxicity and spontaneous cell-mediated cytotoxicity against cells infected with porcine transmissible gastroenteritis virus. Canadian Journal of Comparative Medicine 47(3): 298-303, 1983

Anti-Sp17 monoclonal antibody with antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity activities against human ovarian cancer cells. Medical Oncology 29(4): 2923-2931, 2012

The role of target cells, monocytes, and Fc receptor-bearing lymphocytes in human spontaneous cell-mediated cytotoxicity and antibody-dependent cellular cytotoxicity. Journal of Immunology 125(1): 396-405, 1980

Monocyte macrophage mediated antibody dependent and independent cell mediated cyto toxicity in normals and cancer patients. Proceedings of the American Association for Cancer Research & American Society of Clinical Oncology 22: 372, 1981

Spontaneous cell-mediated cytotoxicity (SCMC) and antibody-dependent cellular cytotoxicity (ADCC) in peripheral blood and draining lymph nodes of patients with mammary carcinoma. Cancer Immunology, ImmunoTherapy 7(1): 65-69, 1979

Human natural cell-mediated cytotoxicity against fetal fibroblasts. IV. Comparison of cytotoxic activity with antibody-dependent cell-mediated cytotoxicity. Scandinavian Journal of Immunology 9(3): 239-245, 1979

Follow-up study on antibody dependent cell-mediated cytotoxicity and cell-mediated cytotoxicity to HBs-antigen conjugated target cells in patients with hepatitis B. Klinische Wochenschrift 58(22): 1251-1255, 1980

The use of a hapten-Fab conjugate to sensitize target cells for antibody-dependent complement-mediated lysis and antibody-dependent cell-mediated cytotoxicity. Journal of Immunological Methods 136(2): 185-191, 1991

Lysis of autologous virus infected cells by direct cytotoxicity and antibody-dependent cell-mediated cytotoxicity in lentiviral infection: equine infectious anemia. Periodicum Biologorum 92(1): 45-46, 1990

Evaluation of spontaneous antibody-dependent cellular cytotoxicity (ADCC) and direct spontaneous lymphocyte-mediated cytotoxicity (SLMC) in patients with neoplasms. Giornale di Clinica Medica 62(9): 609-623, 1981

Anti-donor cell-mediated responses. Pretransplant lymphocyte-mediated cytotoxicity (LMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) in kidney transplantation. Transplantation Proceedings 10(2): 425-427, 1978