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Mullerian inhibiting substance inhibits colony growth of a human ovarian carcinoma cell line



Mullerian inhibiting substance inhibits colony growth of a human ovarian carcinoma cell line



Journal of Clinical Endocrinology and Metabolism 54(5): 1051-1055



Mullerian inhibiting substance (MIS), a fetal testicular product which causes regression of the Mullerian duct in the male mammalian embryo, is being evaluated as an inhibitor of genital tract tumors. In a clonogenic soft agar assay, biologically active MIS inhibits the growth of a human ovarian carcinoma cell line (HOC-21) in a dose-dependent manner when compared to phosphate-buffered saline medium controls, heat-inactivated MIS, or biochemical fractions which lack biological activity (P < 0.05).

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Accession: 043693849

Download citation: RISBibTeXText

PMID: 6895900

DOI: 10.1210/jcem-54-5-1051


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