+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Mycolase II: an enzyme antifungal agent interacts with the polyene antibiotic pimaricin in the treatment of keratomycosis



Mycolase II: an enzyme antifungal agent interacts with the polyene antibiotic pimaricin in the treatment of keratomycosis



International Ophthalmology 5(3): 175-179



An animal model of keratomycosis was used to study the interaction between the new enzyme antifungal compound mycolase II and the polyene antifungal antibiotic pimaricin. Well established corneal infection caused by an ocular pathogenic candida albicans on New Zealand white male rabbits were treated with 3% mycolase II, 5% pimaricin and a combination of 3% mycolase II and 5% pimaricin respectively. The rates of resolution of the corneal lesions for each group of eyes treated by the various drugs were determined and the results were analysed by computer using a two-way analysis of variance to determine the interaction or independence of 3% mycolase II in combination therapy with 5% pimaricin in rabbit keratomycosis. The analysis of variance showed a significant level of positive interaction after each period of treatment. (P less than 0.001).

(PDF emailed within 0-6 h: $19.90)

Accession: 043705733

Download citation: RISBibTeXText

PMID: 6984030

DOI: 10.1007/bf00149150



Related references

In vitro studies on the food preservative antifungal polyene antibiotic pimaricin (natamycin). Microbial associations and interactions in food: proceedings of the 12th International IUMS ICFMH Symposium Budapest Hungary 12-15 July 1983 edited by I Kiss T Deak K Incze: 456, 1984

Treatment of vaginal moniliasis during pregnancy with a new biologic antifungal agent: pimaricin. Canadian Medical Association Journal 95(5): 215-218, 1966

Treatment of vaginal candidiasis during pregnancy with a new biological antifungal agent: pimaricin. Can. med. Ass. J, 95: 5, 215-218, 1966

A study jn the effects of pentamycin and pimaricin, two polyene antifungal antibiotics on the guinea pig heart. Med Pharmacol Exp 12(4): 239-244, 1965

The treatment of keratomycosis with nystatin and pimaricin. Klin. Mbl. Augenheilk, 148: 6, 895-896, 1966

Stimulation of bacteria and actinomycetes by the polyene antibiotic pimaricin in soil dilution plates. Canadian Journal of Microbiology 12(6): 1091-1094, 1966

Natamycin (pimaricin) in the treatment of experimental keratomycosis. Fortschritte der Ophthalmologie 87(3): 237-240, 1990

Effect of 1% pimaricin ophthalmic ointment in the treatment of keratomycosis. Nippon Ganka Gakkai Zasshi 91(2): 304-311, 1987

Pimaricin, a new antifungal antibiotic. Antibiot. Ann., 8, 1958. 878-885, 1958

Pimaricin, a new antifungal antibiotic. Antibiotics Annual 5: 878-885, 1957

Effect of 1 percent pimaricin ophthalmic ointment in the treatment of keratomycosis. Nippon Ganka Gakkai Zasshi 91(2): 304-311, 1987

The antifungal antibiotic pimaricin in dermatology. Zeitschrift für Haut- und Geschlechtskrankheiten 42(14): 585-590, 1967

The structure of neo-enactin A, a new antifungal antibiotic potentiating polyene antifungal antibiotics. Journal of Antibiotics 39(5): 717-720, 1986