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NALL-1, an acute lymphoblastic leukemia cell line with peroxidase activity

Yourno, J.; Samsonoff, W.A.; Willey, A.; Burkhart, P.; Lizzi, F.; Tartaglia, A.

In Vitro 20(11): 884-888

1984


ISSN/ISBN: 0073-5655
PMID: 6097530
DOI: 10.1007/bf02619636
Accession: 043713259

All cells examined from the non-B, non-T acute lymphoblastic leukemia cell line, NALL-1, stained positive both for terminal deoxynucleotidyl transferase and for common ALL antigen. In addition, peroxidase activity was detected by light microscopy in 55 to 75% of cells and peroxidase-positive granules were detected ultrastructurally in greater than 80% of cells. Peroxidase activity in NALL-1 may result from derepression of peroxidase genes or clonal proliferation of a biphenotypic precursor cell.

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