+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Neurotransmitter control of hypothalamic-pituitary-thyroid function in rats

Neurotransmitter control of hypothalamic-pituitary-thyroid function in rats

European Journal of Pharmacology 70(3): 263-271

The possible roles of monoamine neurotransmitters in the regulation of the hypothalamic-pituitary-thyroid axis were examined in the rat. Rats were treated acutely and repeatedly with drugs which are presumed to alter neurotransmitter functional activity. These drugs include neurotransmitter precursors (tryptophan and L-DOPA), synthesis inhibitors (p-chlorophenylalanine and alpha-methyltyrosine), uptake inhibitors (desipramine and zimelidine) and lithium carbonate. The hormone levels measured were hypothalamic TRH and SLI content and serum TSH, T4 and T3. We conclude that augmented serotonergic or dopaminergic activity may inhibit TRH release, but that release from these inhibitions is not sufficient to stimulate TRH release. The release of TRH seems to be mediated by norepinephrine. Lithium treatment results in increased hypothalamic TRH.

(PDF emailed within 1 workday: $29.90)

Accession: 043736236

Download citation: RISBibTeXText

PMID: 6112152

Related references

Hypothalamic and pituitary control of thyroid function. Pan American Health Organization Scientific Publication 292: 33-42, 1974

Pituitary-thyroid function in rats with hypothalamic lesions. Endocrinology 59(5): 593-596, 1956

Depression and alterations in hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axis function in male abstinent methamphetamine abusers. Human Psychopharmacology 28(5): 477-483, 2014

Maturation of human hypothalamic-pituitary-thyroid function and control. Thyroid 10(3): 229-234, 2000

Maturation of hypothalamic pituitary control of thyroid function in the human fetus. Pediatric Research 4(5): 457, 1970

Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes dysfunction. Journal of Endocrinological Investigation 39(10): 1115-1124, 2017

Disturbed function of pituitary thyroid axis in brattleboro rats with hypothalamic diabetes insipidus. Japanese Journal of Pharmacology 32(SUPPL): 84P, 1982

Increased activity of the hypothalamic-pituitary-adrenal axis of rats exposed to alcohol in utero: role of altered pituitary and hypothalamic function. Molecular and Cellular Neurosciences 16(4): 515-528, 2000

Studies on dys function of hypothalamic pituitary thyroid axis part 2 studies on dys function of hypothalamic pituitary thyroid axis in breast cancer. Medical Journal of Kobe University 36(3): 9-16, 1977

Studies on dys function of hypothalamic pituitary thyroid axis part 1 studies on dys function of hypothalamic pituitary thyroid axis in chronic thyroiditis. Medical Journal of Kobe University 36(3): 1-8, 1977

Hypothalamic and brain thyrotropin-releasing hormone content and pituitary-thyroid function in histidine-deficient rats. Endocrinology 101(2): 442-446, 1977

Effects of ethanol and control liquid diets on the hypothalamic-pituitary-thyroid axis of male Fischer-344 rats. Alcoholism, Clinical and Experimental Research 16(6): 1130-1137, 1992

Impairment of hypothalamic-pituitary-thyroid function in rats treated with human recombinant tumor necrosis factor-alpha (cachectin). Endocrinology 125(1): 76-84, 1989

Neuroendocrine control of the pituitary TSH secretion. VI. Effect of long term administration of synthetic thyrotropin-releasing hormone (TRH) on pituitary-thyroid function in rats. Kobe Journal of Medical Sciences 18(1): 15-19, 1972

The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study. Pharmacological Reports 71(2): 243-247, 2019