+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

New perspectives on therapeutic application of nitrates as vasodilator agents for severe chronic heart failure

, : New perspectives on therapeutic application of nitrates as vasodilator agents for severe chronic heart failure. American Journal of Medicine 74(6b): 61-72

Although nitrates produce marked decreases in ventricular filling pressures in patients with severe heart failure, their therapeutic value has long been believed to be limited because they were thought to exert minimal arterial dilating effects. Recently, however, new conceptual approaches to vasodilator drugs have been developed that have challenged this traditional view. These new perspectives indicate that nitrates exert dilator actions on both the arterial and venous circulations, and reduce both preload and afterload; such balanced circulatory responses are particularly evident when large doses of these drugs are used. Cardiac output increases markedly with nitrates in patients with a greatly increased systemic vascular resistance before treatment or with significant mitral regurgitation. The major reason for the limited increases in cardiac output noted in previous studies is the inclusion of patients with heart failure whose pretreatment values for cardiac output were within normal limits; in these persons nitrates markedly activate neurohumoral vasoconstrictor mechanisms that counteract the arterial dilating actions of these drugs. Long-term nitrate therapy attenuates exercise-induced increases in pulmonary venous pressures, which permit patients to undergo repeated submaximal exercise with fewer symptoms; this improves physical conditioning and exercise capacity, even in the absence of drug-related changes in cardiac output. The long-term hemodynamic and clinical benefits of nitrates in heart failure have been confirmed by two independent randomized double-blind placebo-controlled clinical trials.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 043745015

PMID: 6859073

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Tembuyser, L.; Ligtenberg, M.J.L.; Normanno, N.; Delen, S.; van Krieken, J.Han.; Dequeker, E.M.C., 2015: Higher quality of molecular testing, an unfulfilled priority: Results from external quality assessment for KRAS mutation testing in colorectal cancer. Precision medicine is now a key element in clinical oncology. RAS mutational status is a crucial predictor of responsiveness to anti-epidermal growth factor receptor agents in metastatic colorectal cancer. In an effort to guarantee high-quality te...

Shaw, W. A., 1910: The birds of Northamptonshire and neighbourhood. Report for 1909. Journal of the Natural History Society Northampton, 15 176-178

Hendriks, D.; van Sande, M.; Scharpé, S., 1986: Colorimetric assay for carboxypeptidase N in serum. Clinica Chimica Acta; International Journal of Clinical Chemistry 157(1): 103-108

Pachico, D., 1980: Applying efficiency analysis to small farms in low income countries: some theorectical and empirical considerations. Cornell international agricultural mimeograph Cornell University Department of Agricultural Economics: 80 (84)

Przychodzki M., 1975: Osseal muscular decortication as an effective method for treatment of pseudoarthrosis. Chirurgia Narzadow Ruchu i Ortopedia Polska 40(1): 23-29

Dree, Robert E., 1954: A field observation method of aging broods of Wood Ducks, Aix sponsa. An aging method is presented for broods of wood ducks based on comparative size of adult hen and duckling and on duckling habits. The criteria are drawn from observations of 8 broods of known ages in river bottom habitat of Iowa.

Wagner, H.J., 2001: Sensory brain areas in mesopelagic fishes. Four areas of the brain that receive primary projections from chemical senses ([1] olfactory bulb, [2] facial and vagal lobes), the eye ([3] optic tectum), and somato- and mechanosensory systems such as the lateral line, vestibular and auditory sy...

Walker, R.F.; Codd, E.E., 1985: Neuroimmunomodulatory interactions of norepinephrine and serotonin. Monoamine neuroleptics alter rodents responses to immunization, suggesting that norepinephrine (NE) and serotonin (5HT) are neuroimmunomodulatory in these animals. Although endocrine factors participate in their mechanism(s) of action, recent stud...

Izumi, C.M.S.; Constantino, V.R.L.; Temperini, M.L.A., 2006: Spectroscopic characterization of polyaniline formed by using copper(II) in homogeneous and MCM-41 molecular sieve media. This work emphasizes the important role of the synthetic parameters in the structure of the polymeric material obtained in the aniline polymerization. The polymers formed by the oxidative polymerization of aniline by copper(II) ions in acidic aque...

Tsuchida, W. S.; Uchida, I. A., 1974: Chromosome aberrations in spermatocytes and oocytes of mice irradiated prenatally. 5 mice were exposed to a single dose of 150 R whole-body gamma -irradiation on the 12th day of pregnancy. The oocytes and spermatocytes collected from the F1 progeny at 10-12 wk of age were examined for chromosome aberrations in metaphase I and co...