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Norepinephrine and gamma-aminobutyric acid in amyotrophic lateral sclerosis



Norepinephrine and gamma-aminobutyric acid in amyotrophic lateral sclerosis



Neurology 30(1): 98-101



Patients with amyotrophic lateral sclerosis have increased levels of the neutrotransmitter norepinephrine in blood and cerebrospinal fluid and depressed levels of the inhibitory neurotransmitter gamma-aminobutyric acid in cerebrospinal fluid. These neurochemical alterations are most marked in patients bedridden with advanced disease, appear interrelated, and lead to cardiovascular alterations in patients with amyotrophic lateral sclerosis.

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Accession: 043760397

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PMID: 7188643


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