+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

On participation of the autonomic nervous system in the mechanisms of chemical carcinogenesis



On participation of the autonomic nervous system in the mechanisms of chemical carcinogenesis



Neoplasma 29(3): 301-307



With the view of studying the role of autonomic nervous system in chemical carcinogenesis mechanism in outbred white male rats, chronically treated with NDEA, there has been investigated the modifying effect of some neurotropic pharmacological drugs which cause either stimulation or inhibition of: 1. adrenergic processes (noradrenalin, isoproterenol, clonidine, pyrroxane and propranolol); 2. cholinergic processes (proserine and atropine); 3. the function of the central nervous system (CNS)--caffeine and ethanol. Pharmacological activation of alpha-adrenoreceptors or blocking of both beta-adrenoreceptors and cholinoreceptors has been revealed to stimulate hepatocarcinogenesis. On the contrary, the administration of alpha-adrenoreceptors antagonist or beta-adrenoreceptor and cholinoreceptors agonists inhibited the process of carcinogenic transformation. Caffeine, being the CNS stimulator, has significantly promoted carcinogenesis, while ethanol has practically prevented NDEA effect. Clonidine has also demonstrated its anticarcinogenic action. The obtained data are being discussed in connection with chemical carcinogenesis influence upon the CNS integrative function in control and regulation of tissue homeostasis.

(PDF emailed within 1 workday: $29.90)

Accession: 043804501

Download citation: RISBibTeXText

PMID: 6127635


Related references

Participation of the autonomic nervous system in the mechanisms of chemical carcinogenesis. Neoplasma (Bratislava) 29(3): 301-308, 1982

Participation of peripheral sensory structures of autonomic nervous system in the mechanisms of neuroimmune interactions. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 100(10): 1138-1151, 2015

Experimental investigation of participation of the autonomic nervous system in functional mechanisms of auricular diagnosis in dogs. Wiener Tierarztliche Monatsschrift 76(6): 173-179, 1989

Studies on the autonomic nervous function autonomic nervous mechanisms of sportsman's bradycardia and the correlation between autonomic nervous activity and autonomic nervous reflex function. Medical Journal of Kagoshima University 43(3): 337-348, 1991

The role of the sympathetic nervous system in mediating the action of analgesic drugs on the lens reserpine autonomic methadone autonomic mouse methadone autonomic epinephrine autonomic norepinephrine autonomic phenylephrine autonomic metaraminol autonomic iproniazid autonomic nialamide autonomic. Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie 259(2): 201-202, 1968

Autonomic nervous system and diseases of the digestive tract organs The autonomic nervous system II Clinical and therapeutical aspects of autonomic functional disturbance. 1966

Autonomic nervous system and skin diseases The autonomic nervous system II Clinical and therapeutical aspects of autonomic functional disturbance. 1966

Central nervous system mechanisms integrating taste and the autonomic nervous system. Appetite 12(1): 79, 1989

The participation of the autonomic nervous system in hereditary thesaurismosis. J Acta Med Acad Sci Hung 21(4): 435-443, 1965

Participation of the peripheral autonomic nervous system in emesis. Society for Neuroscience Abstracts 16(1): 864, 1990

Participation of the autonomic nervous system in the cardiovascular effects of milrinone. Life Sciences 38(21): 1967-1974, 1986

The participation of the autonomic nervous system in the mechanism of action of acupuncture. American Journal of Acupuncture 19(1): 21-28, 1991

Participation of autonomic nervous system in the pathogenesis of Chagas disease. Acta Physiologica, Pharmacologica et Therapeutica Latinoamericana 44(4): 109-123, 1994

A contribution to the participation of the autonomic nervous system in the pathogenesis of trypanosomiasis. Trudy Turkm S Kh Inst (8): 95-108, 1956

Participation of the autonomic nervous system in the mobilization of antidiuretic hormones. Endokrinologie 34(3): 162-167, 1957