+ Translate

Oscillations in the phosphofructokinase--fructose 1,6-bisphosphatase cycle. II. Influence of fructose 1,6-bisphosphatase on the character of oscillatory states

, : Oscillations in the phosphofructokinase--fructose 1,6-bisphosphatase cycle. II. Influence of fructose 1,6-bisphosphatase on the character of oscillatory states. Biomedica Biochimica Acta 42(6): 609-621

The dynamic behaviour of an open futile cycle composed of phosphofructokinase and fructose 1,6-bisphosphatase has been investigated in a homogeneous reconstituted enzyme system in which the two enzymes cooperate with pyruvate kinase, adenylate kinase and glucose 6-phosphate isomerase. By the kinetic cooperation of phosphofructokinase and fructose 1,6-bisphosphatase various types of dynamic patterns can be generated. In the absence of fructose 1,6-bisphosphatase oscillations do not occur. As experimentally demonstrated, in a definite region of maximum activities of fructose 1,6-bisphosphatase sustained oscillations originate while at higher concentrations of the enzyme damped oscillations appear. At increasing concentrations of fructose 1,6-bisphosphatase damping is strengthened. Finally, at very high concentrations of fructose 1,6-bisphosphatase the metabolites relax monotonously to the stationary states. The observed oscillatory phenomena are mainly caused by the antagonistic effects of AMP on the kinetics of phosphofructokinase and fructose 1,6-bisphosphatase.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 043855498

PMID: 6314995

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Maleki, M.; Tristani, F.E., 1974: Coronary arteriography in situs inversus dextrocardia. Chest 65(2): 220-222

Ishihara, Michihiro; Seko, Tomokazu, 2007: Phenotypic plasticity of insects for seasonal adaptations. Japanese Journal of Ecology (Otsu) 57(1): 27-32

Zavgorodniĭ, L.G.; Kurapov, E.P., 1972: Changes in circulating blood volume associated with surgery on the digestive tract. Vestnik Khirurgii Imeni I. I. Grekova 109(7): 82-87

Nemec D.; Ackermand D., 1987: Baotite, a rock-forming mineral of Ba-rich hyperpotassic dyke rocks. Neues Jahrbuch fuer Mineralogie: shefte. 1987; 1, Pages 31-42. 1987.

Baldwin J.; Morris G.M., 1983: Reexamination of the contributions of aerobic and anaerobic energy production during swimming in the bivalve mollusk limaria fragilis family limidae. The file shell L. fragilis displays a slow sustained style of swimming indicative of basically aerobic mechanisms of ATP production. Although it had been proposed that anaerobic glycolysis and arginine phosphate did not contribute to powering swim...

Buscaino, G.A.; Carella, A., 1969: Arteriographic documentation and surgical treatment of an enormous supraclinoid aneurysm. Acta Neurologica 24(4): 517-523

Lutz, P.G.; Moog-Lutz, C.; Coumau-Gatbois, E.; Kobari, L.; Di Gioia, Y.; Cayre, Y.E., 2000: Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells. Hematopoiesis depends on a pool of quiescent hematopoietic stem/progenitor cells. When exposed to specific cytokines, a portion of these cells enters the cell cycle to generate an amplified progeny. Myeloblastin (MBN) initially was described as in...

Quinn, P.C.; Siqueland, E.R.; Bomba, P.C., 1985: Delayed recognition memory for orientation by human infants. The familiarization/novelty preference paradigm was employed to study the effect of a delay (between the end of the familiarization phase and the beginning of the test phase) on discrimination of the orientation of square-wave gratings by 2- and 3...

Romert P.; Matthiessen M.E., 1992: Ultrastructural and morphometric study of hepatocytes from near term minipig fetuses exposed to ethanol in vivo. Hepatocytes of near-term minipig fetuses were studied after their mothers had received a daily addition of 3 g/kg body weight of ethanol to the ordinary sufficient fodder during the last half of pregnancy. The ethanol-exposed hepatocytes were eval...

Chansoo Kim, Myoung-Seok Suh, 2013: Prospects of using Bayesian model averaging for the calibration of one-month forecasts of surface air temperature over South Korea. In this study, we investigated the prospect of calibrating probabilistic forecasts of surface air temperature (SAT) over South Korea by using Bayesian model averaging (BMA). We used 63 months of simulation results from four regional climate models...